Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Paola Dal Cin; Bradley J Quade; David M Neskey; Michael S Kleinman; Stanislawa Weremowicz; Cynthia C Morton

doi:10.1002/gcc.10159

Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Paola Dal Cin, Bradley J Quade, David M Neskey, Michael S Kleinman, Stanislawa Weremowicz, Cynthia C Morton

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.

Original language	English
Pages (from-to)	205-6
Number of pages	2
Journal	Genes, Chromosomes & Cancer
Volume	36
Issue number	2
DOIs	https://doi.org/10.1002/gcc.10159
Publication status	Published - Feb 2003

Keywords

Adult
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 14
Cytogenetic Analysis
Female
Humans
Leiomyoma
Leiomyomatosis
Translocation, Genetic
Uterine Neoplasms
Vascular Neoplasms
Journal Article

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10.1002/gcc.10159

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title = "Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)",

abstract = "Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.",

keywords = "Adult, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 14, Cytogenetic Analysis, Female, Humans, Leiomyoma, Leiomyomatosis, Translocation, Genetic, Uterine Neoplasms, Vascular Neoplasms, Journal Article",

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doi = "10.1002/gcc.10159",

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TY - JOUR

T1 - Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

AU - Dal Cin, Paola

AU - Quade, Bradley J

AU - Neskey, David M

AU - Kleinman, Michael S

AU - Weremowicz, Stanislawa

AU - Morton, Cynthia C

PY - 2003/2

Y1 - 2003/2

N2 - Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.

AB - Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.

KW - Adult

KW - Chromosomes, Human, Pair 12

KW - Chromosomes, Human, Pair 14

KW - Cytogenetic Analysis

KW - Female

KW - Humans

KW - Leiomyoma

KW - Leiomyomatosis

KW - Translocation, Genetic

KW - Uterine Neoplasms

KW - Vascular Neoplasms

KW - Journal Article

U2 - 10.1002/gcc.10159

DO - 10.1002/gcc.10159

M3 - Article

C2 - 12508249

SN - 1045-2257

VL - 36

SP - 205

EP - 206

JO - Genes, Chromosomes & Cancer

JF - Genes, Chromosomes & Cancer

IS - 2

ER -

Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Abstract

Keywords

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