TY - JOUR
T1 - Inverse correlation between heart rate variability and heart rate demonstrated by linear and nonlinear analysis
AU - Kazmi, Syed Zaki Hassan
AU - Zhang, Henggui
AU - Aziz, Wajid
AU - Monfredi, Oliver
AU - Abbas, Syed Ali
AU - Shah, Saeed Arif
AU - Kazmi, Syeda Sobia Hassan
AU - Butt, Wasi Haider
PY - 2016/6/23
Y1 - 2016/6/23
N2 - The dynamical fluctuations in the rhythms of biological systems provide valuable information about the underlying functioning of these systems. During the past few decades analysis of cardiac function based on the heart rate variability (HRV; variation in R wave to R wave intervals) has attracted great attention, resulting in more than 17000-publications (PubMed list). However, it is still controversial about the underling mechanisms of HRV. In this study, we performed both linear (time domain and frequency domain) and nonlinear analysis of HRV data acquired from humans and animals to identify the relationship between HRV and heart rate (HR). The HRV data consists of the following groups: (a) human normal sinus rhythm (n = 72); (b) human congestive heart failure (n = 44); (c) rabbit sinoatrial node cells (SANC; n = 67); (d) conscious rat (n = 11). In both human and animal data at variant pathological conditions, both linear and nonlinear analysis techniques showed an inverse correlation between HRV and HR, supporting the concept that HRV is dependent on HR, and therefore, HRV cannot be used in an ordinary manner to analyse autonomic nerve activity of a heart.
AB - The dynamical fluctuations in the rhythms of biological systems provide valuable information about the underlying functioning of these systems. During the past few decades analysis of cardiac function based on the heart rate variability (HRV; variation in R wave to R wave intervals) has attracted great attention, resulting in more than 17000-publications (PubMed list). However, it is still controversial about the underling mechanisms of HRV. In this study, we performed both linear (time domain and frequency domain) and nonlinear analysis of HRV data acquired from humans and animals to identify the relationship between HRV and heart rate (HR). The HRV data consists of the following groups: (a) human normal sinus rhythm (n = 72); (b) human congestive heart failure (n = 44); (c) rabbit sinoatrial node cells (SANC; n = 67); (d) conscious rat (n = 11). In both human and animal data at variant pathological conditions, both linear and nonlinear analysis techniques showed an inverse correlation between HRV and HR, supporting the concept that HRV is dependent on HR, and therefore, HRV cannot be used in an ordinary manner to analyse autonomic nerve activity of a heart.
UR - http://www.scopus.com/inward/record.url?scp=84976589808&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0157557
DO - 10.1371/journal.pone.0157557
M3 - Article
AN - SCOPUS:84976589808
VL - 11
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0157557
ER -