Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications

Yanhao Hou, Weiguang Wang (Corresponding), Paulo Jorge Da Silva Bartolo

Research output: Contribution to journalArticlepeer-review

Abstract

Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approach in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and G oxide at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, G oxide seems to show some cytotoxicity, particular at high contents.
Original languageEnglish
Pages (from-to)61-69
JournalInternational Journal of Bioprinting
Volume6
Issue number2
Early online date21 Apr 2020
DOIs
Publication statusPublished - 2020

Keywords

  • Biomanufactoring
  • Graphene
  • Graphene oxide
  • Poly (ε-caprolactone)
  • Scaffolds
  • Tissue engineering

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