Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

Antony Payton, Fabio Miyajima, William Ollier, Patrick Rabbitt, Andrew Pickles, Volkmar Weiss, Neil Pendleton, Michael Horan

    Research output: Contribution to journalArticlepeer-review


    NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.
    Original languageEnglish
    Pages (from-to)351-352
    Number of pages1
    JournalNeurobiology of Aging
    Issue number2
    Publication statusPublished - Feb 2010


    • Association
    • Cognition
    • Genes
    • NAD(P)H dehydrogenase quinone 2
    • NQO2
    • Polymorphism


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