Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

Antony Payton; Fabio Miyajima; William Ollier; Patrick Rabbitt; Andrew Pickles; Volkmar Weiss; Neil Pendleton; Michael Horan

doi:10.1016/j.neurobiolaging.2008.04.014

Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

Antony Payton, Fabio Miyajima, William Ollier, Patrick Rabbitt, Andrew Pickles, Volkmar Weiss, Neil Pendleton, Michael Horan

Research output: Contribution to journal › Article › peer-review

Abstract

NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.

Original language	English
Pages (from-to)	351-352
Number of pages	1
Journal	Neurobiology of Aging
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.04.014
Publication status	Published - Feb 2010

Keywords

Association
Cognition
Genes
NAD(P)H dehydrogenase quinone 2
NQO2
Polymorphism

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10.1016/j.neurobiolaging.2008.04.014

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title = "Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline",

abstract = "NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.",

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T1 - Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

AU - Payton, Antony

AU - Miyajima, Fabio

AU - Ollier, William

AU - Rabbitt, Patrick

AU - Pickles, Andrew

AU - Weiss, Volkmar

AU - Pendleton, Neil

AU - Horan, Michael

PY - 2010/2

Y1 - 2010/2

N2 - NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.

AB - NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.

KW - Association

KW - Cognition

KW - Genes

KW - NAD(P)H dehydrogenase quinone 2

KW - NQO2

KW - Polymorphism

U2 - 10.1016/j.neurobiolaging.2008.04.014

DO - 10.1016/j.neurobiolaging.2008.04.014

M3 - Article

C2 - 18538895

SN - 0197-4580

VL - 31

SP - 351

EP - 352

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 2

ER -

Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

Abstract

Keywords

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