Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

John D. Bowes; Catherine Potter; Laura J. Gibbons; Kimme Hyrich; Darren Plant; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS); Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Jane Worthington; Anne Barton

doi:10.1097/FPC.0b013e328328d51f

Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

John D. Bowes, Catherine Potter, Laura J. Gibbons, Kimme Hyrich, Darren Plant, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Jane Worthington, Anne Barton

Research output: Contribution to journal › Article › peer-review

Abstract

The introduction of anti-tumour necrosis factor (TNF) agents has greatly improved the treatment of rheumatoid arthritis; however, a significant proportion of patients fail to respond to therapy. We hypothesized that genes within the TNF receptor superfamily member 1B signalling pathway contribute towards the observed variation in patient response. This was tested by genotyping 73 singlenucleotide polymorphisms (SNPs) from six candidate genes (DUSP1, HRB, IKBKAP, MAP3K1, MAP3K14 and TANK) in a large UK cohort of rheumatoid arthritis patients (n=642). Two SNPs [rs96844 (MAP3K1) and rs4792847 (MAP3K14)] showed evidence of association (P

Original language	English
Pages (from-to)	319-323
Number of pages	4
Journal	Pharmacogenetics and Genomics
Volume	19
Issue number	4
DOIs	https://doi.org/10.1097/FPC.0b013e328328d51f
Publication status	Published - Apr 2009

Keywords

Anti-tumour necrosis factor
Association
Candidate
Gene
Pathway
Response
Rheumatoid arthritis

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10.1097/FPC.0b013e328328d51f

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Bowes, J. D., Potter, C., Gibbons, L. J., Hyrich, K., Plant, D., Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Morgan, A. W., Wilson, A. G., Isaacs, J. D., Worthington, J., & Barton, A. (2009). Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenetics and Genomics, 19(4), 319-323. https://doi.org/10.1097/FPC.0b013e328328d51f

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title = "Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients",

abstract = "The introduction of anti-tumour necrosis factor (TNF) agents has greatly improved the treatment of rheumatoid arthritis; however, a significant proportion of patients fail to respond to therapy. We hypothesized that genes within the TNF receptor superfamily member 1B signalling pathway contribute towards the observed variation in patient response. This was tested by genotyping 73 singlenucleotide polymorphisms (SNPs) from six candidate genes (DUSP1, HRB, IKBKAP, MAP3K1, MAP3K14 and TANK) in a large UK cohort of rheumatoid arthritis patients (n=642). Two SNPs [rs96844 (MAP3K1) and rs4792847 (MAP3K14)] showed evidence of association (P",

keywords = "Anti-tumour necrosis factor, Association, Candidate, Gene, Pathway, Response, Rheumatoid arthritis",

author = "Bowes, {John D.} and Catherine Potter and Gibbons, {Laura J.} and Kimme Hyrich and Darren Plant and {Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)} and Morgan, {Ann W.} and Wilson, {Anthony G.} and Isaacs, {John D.} and Jane Worthington and Anne Barton",

year = "2009",

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doi = "10.1097/FPC.0b013e328328d51f",

language = "English",

volume = "19",

pages = "319--323",

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Bowes, JD, Potter, C, Gibbons, LJ, Hyrich, K , Plant, D, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Morgan, AW, Wilson, AG, Isaacs, JD, Worthington, J & Barton, A 2009, 'Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients', Pharmacogenetics and Genomics, vol. 19, no. 4, pp. 319-323. https://doi.org/10.1097/FPC.0b013e328328d51f

Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. / Bowes, John D.; Potter, Catherine; Gibbons, Laura J. et al.
In: Pharmacogenetics and Genomics, Vol. 19, No. 4, 04.2009, p. 319-323.

Research output: Contribution to journal › Article › peer-review

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AU - Bowes, John D.

AU - Potter, Catherine

AU - Gibbons, Laura J.

AU - Hyrich, Kimme

AU - Plant, Darren

AU - Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)

AU - Morgan, Ann W.

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AU - Worthington, Jane

AU - Barton, Anne

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AB - The introduction of anti-tumour necrosis factor (TNF) agents has greatly improved the treatment of rheumatoid arthritis; however, a significant proportion of patients fail to respond to therapy. We hypothesized that genes within the TNF receptor superfamily member 1B signalling pathway contribute towards the observed variation in patient response. This was tested by genotyping 73 singlenucleotide polymorphisms (SNPs) from six candidate genes (DUSP1, HRB, IKBKAP, MAP3K1, MAP3K14 and TANK) in a large UK cohort of rheumatoid arthritis patients (n=642). Two SNPs [rs96844 (MAP3K1) and rs4792847 (MAP3K14)] showed evidence of association (P

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KW - Pathway

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Bowes JD, Potter C, Gibbons LJ, Hyrich K , Plant D, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) et al. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenetics and Genomics. 2009 Apr;19(4):319-323. doi: 10.1097/FPC.0b013e328328d51f

Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

Abstract

Keywords

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