Investigation of motion induced errors in scatter correction for the HRRT brain scanner

Jose M. Anton-Rodriguez; Merence Sibomana; Matthew D. Walker; Marc C. Huisman; Julian C. Matthews; Maria Feldmann; Sune H. Keller; Marie Claude Asselin

doi:10.1109/NSSMIC.2010.5874334

Investigation of motion induced errors in scatter correction for the HRRT brain scanner

Jose M. Anton-Rodriguez, Merence Sibomana, Matthew D. Walker, Marc C. Huisman, Julian C. Matthews, Maria Feldmann, Sune H. Keller, Marie Claude Asselin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space. © 2010 IEEE.

Original language	English
Title of host publication	IEEE Nuclear Science Symposium Conference Record\|IEEE Nucl. Sci. Symp. Conf. Rec.
Pages	2935-2940
Number of pages	5
DOIs	https://doi.org/10.1109/NSSMIC.2010.5874334
Publication status	Published - 2010
Event	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN Duration: 1 Jul 2010 → …

Conference

Conference	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
City	Knoxville, TN
Period	1/07/10 → …

Keywords

brain
image motion analysis
image reconstruction
image registration
image segmentation
medical image processing
nonlinear filters
positron emission tomography
radioactive tracers
&#x03BC
-map reconstruction
HRRT brain scanner
PET scans
TXTV
attenuation correction
automated image registration
brain segmentation
emission data
head
image artefacts
image blurring
motion induced errors
nonlinear filtering
patient motion
quantification errors
regional radioactivity concentrations
scatter correction
scatter scaling factors
transmission data

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10.1109/NSSMIC.2010.5874334

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Anton-Rodriguez, J. M., Sibomana, M., Walker, M. D., Huisman, M. C., Matthews, J. C., Feldmann, M., Keller, S. H., & Asselin, M. C. (2010). Investigation of motion induced errors in scatter correction for the HRRT brain scanner. In IEEE Nuclear Science Symposium Conference Record|IEEE Nucl. Sci. Symp. Conf. Rec. (pp. 2935-2940) https://doi.org/10.1109/NSSMIC.2010.5874334

@inproceedings{9c67cd202d94425aa0871540382e903c,

title = "Investigation of motion induced errors in scatter correction for the HRRT brain scanner",

abstract = "Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space. {\textcopyright} 2010 IEEE.",

keywords = "brain, image motion analysis, image reconstruction, image registration, image segmentation, medical image processing, nonlinear filters, positron emission tomography, radioactive tracers, &#x03BC, -map reconstruction, HRRT brain scanner, PET scans, TXTV, attenuation correction, automated image registration, brain segmentation, emission data, head, image artefacts, image blurring, motion induced errors, nonlinear filtering, patient motion, quantification errors, regional radioactivity concentrations, scatter correction, scatter scaling factors, transmission data",

author = "Anton-Rodriguez, {Jose M.} and Merence Sibomana and Walker, {Matthew D.} and Huisman, {Marc C.} and Matthews, {Julian C.} and Maria Feldmann and Keller, {Sune H.} and Asselin, {Marie Claude}",

year = "2010",

doi = "10.1109/NSSMIC.2010.5874334",

language = "English",

isbn = "9781424491063",

pages = "2935--2940",

booktitle = "IEEE Nuclear Science Symposium Conference Record|IEEE Nucl. Sci. Symp. Conf. Rec.",

note = "2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 ; Conference date: 01-07-2010",

}

Anton-Rodriguez, JM, Sibomana, M, Walker, MD, Huisman, MC, Matthews, JC, Feldmann, M, Keller, SH & Asselin, MC 2010, Investigation of motion induced errors in scatter correction for the HRRT brain scanner. in IEEE Nuclear Science Symposium Conference Record|IEEE Nucl. Sci. Symp. Conf. Rec.. pp. 2935-2940, 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010, Knoxville, TN, 1/07/10. https://doi.org/10.1109/NSSMIC.2010.5874334

TY - GEN

T1 - Investigation of motion induced errors in scatter correction for the HRRT brain scanner

AU - Anton-Rodriguez, Jose M.

AU - Sibomana, Merence

AU - Walker, Matthew D.

AU - Huisman, Marc C.

AU - Matthews, Julian C.

AU - Feldmann, Maria

AU - Keller, Sune H.

AU - Asselin, Marie Claude

PY - 2010

Y1 - 2010

N2 - Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space. © 2010 IEEE.

AB - Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space. © 2010 IEEE.

KW - brain

KW - image motion analysis

KW - image reconstruction

KW - image registration

KW - image segmentation

KW - medical image processing

KW - nonlinear filters

KW - positron emission tomography

KW - radioactive tracers

KW - &#x03BC

KW - -map reconstruction

KW - HRRT brain scanner

KW - PET scans

KW - TXTV

KW - attenuation correction

KW - automated image registration

KW - brain segmentation

KW - emission data

KW - head

KW - image artefacts

KW - image blurring

KW - motion induced errors

KW - nonlinear filtering

KW - patient motion

KW - quantification errors

KW - regional radioactivity concentrations

KW - scatter correction

KW - scatter scaling factors

KW - transmission data

U2 - 10.1109/NSSMIC.2010.5874334

DO - 10.1109/NSSMIC.2010.5874334

M3 - Conference contribution

SN - 9781424491063

SP - 2935

EP - 2940

BT - IEEE Nuclear Science Symposium Conference Record|IEEE Nucl. Sci. Symp. Conf. Rec.

T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010

Y2 - 1 July 2010

ER -

Investigation of motion induced errors in scatter correction for the HRRT brain scanner

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Keywords

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