Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.

Rebecca S Samson; Manuel J Cardoso; Nils Muhlert; Varun Sethi; Claudia Am Wheeler-Kingshott; Maria Ron; Sebastian Ourselin; David H Miller; Declan T Chard

doi:10.1177/1352458514522537

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.

Rebecca S Samson, Manuel J Cardoso, Nils Muhlert, Varun Sethi, Claudia Am Wheeler-Kingshott, Maria Ron, Sebastian Ourselin, David H Miller, Declan T Chard

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS). OBJECTIVE: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups. METHODS: Forty-four relapsing-remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1×1×1mm(3) T1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band. RESULTS: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls (p

Original language	English
Journal	Multiple sclerosis (Houndmills, Basingstoke, England)
Volume	20
Issue number	10
DOIs	https://doi.org/10.1177/1352458514522537
Publication status	Published - Sept 2014

Keywords

Multiple sclerosis
cortical grey matter
magnetization transfer ratio

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10.1177/1352458514522537

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title = "Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.",

abstract = "BACKGROUND: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS). OBJECTIVE: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups. METHODS: Forty-four relapsing-remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1×1×1mm(3) T1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band. RESULTS: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls (p",

keywords = "Multiple sclerosis, cortical grey matter, magnetization transfer ratio",

author = "Samson, {Rebecca S} and Cardoso, {Manuel J} and Nils Muhlert and Varun Sethi and Wheeler-Kingshott, {Claudia Am} and Maria Ron and Sebastian Ourselin and Miller, {David H} and Chard, {Declan T}",

year = "2014",

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doi = "10.1177/1352458514522537",

language = "English",

volume = "20",

journal = "Multiple sclerosis (Houndmills, Basingstoke, England)",

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TY - JOUR

T1 - Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.

AU - Samson, Rebecca S

AU - Cardoso, Manuel J

AU - Muhlert, Nils

AU - Sethi, Varun

AU - Wheeler-Kingshott, Claudia Am

AU - Ron, Maria

AU - Ourselin, Sebastian

AU - Miller, David H

AU - Chard, Declan T

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS). OBJECTIVE: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups. METHODS: Forty-four relapsing-remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1×1×1mm(3) T1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band. RESULTS: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls (p

AB - BACKGROUND: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS). OBJECTIVE: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups. METHODS: Forty-four relapsing-remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1×1×1mm(3) T1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band. RESULTS: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls (p

KW - Multiple sclerosis

KW - cortical grey matter

KW - magnetization transfer ratio

U2 - 10.1177/1352458514522537

DO - 10.1177/1352458514522537

M3 - Article

C2 - 24552746

SN - 1352-4585

VL - 20

JO - Multiple sclerosis (Houndmills, Basingstoke, England)

JF - Multiple sclerosis (Houndmills, Basingstoke, England)

IS - 10

ER -

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups.

Abstract

Keywords

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