Abstract
The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-α) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12 - 17 corresponding to the period of weight loss after induction of leukaemia, IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-α plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 45-49 |
| Number of pages | 4 |
| Journal | European cytokine network |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 1997 |
Keywords
- Cachexia
- Cytokines
- IL-6
- Rat
- T-cell leukaemia
