Ionic signaling in physiology and pathophysiology of astroglia

Alexei Verkhratsky, Vladimir Parpura

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    Excitability of astrocytes is based on spatio-temporally organized fluctuations of intracellular concentrations of two ions, Ca2+ and Na+. This is dictated by ionic movements between intracellular compartments, and between the cytosol and the extracellular space, achieved by concentration-driven diffusion through membrane channels or transport by pumps and exchangers. Neuronal activity triggers transient elevation of Ca2+ and Na+ in astrocytes; changes in cytosolic levels of these ions translate into functional responses through multiple molecular cascades. Aberrant ionic signaling contributes to pathological reactions of astroglia in various forms of neurological diseases, such as stroke, epilepsy, and various neurodegenerative and neuropsychiatric disorders.

    Original languageEnglish
    Title of host publicationPathological Potential of Neuroglia
    Subtitle of host publicationPossible New Targets for Medical Intervention
    PublisherSpringer Nature
    Chapter2
    Pages13-31
    Number of pages19
    ISBN (Electronic)9781493909742
    ISBN (Print)1493909738, 9781493909735
    DOIs
    Publication statusPublished - 1 Mar 2014

    Keywords

    • Astroglia
    • Ca<sup>2+</sup> channels
    • Calcium signaling
    • Endoplasmic reticulum
    • Ionotropic receptors
    • Metabotropic receptors
    • Mitochondria
    • Na<sup>+</sup>-Ca<sup>2+</sup> exchanger
    • Sodium signaling
    • TRP channels

    Fingerprint

    Dive into the research topics of 'Ionic signaling in physiology and pathophysiology of astroglia'. Together they form a unique fingerprint.

    Cite this