Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

Hugh D. Piggins, David J. Cutler, Benjamin Rusak

    Research output: Contribution to journalArticlepeer-review


    Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. © 1995.
    Original languageEnglish
    Pages (from-to)475-479
    Number of pages4
    JournalBrain Research Bulletin
    Issue number5
    Publication statusPublished - 1995


    • Circadian rhythm
    • Electrophysiology
    • Substance P
    • Suprachiasmatic nucleus
    • Tachykinin


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