Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

Hugh D. Piggins; David J. Cutler; Benjamin Rusak

Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

Hugh D. Piggins, David J. Cutler, Benjamin Rusak

Research output: Contribution to journal › Article › peer-review

Abstract

Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. © 1995.

Original language	English
Pages (from-to)	475-479
Number of pages	4
Journal	Brain Research Bulletin
Volume	37
Issue number	5
Publication status	Published - 1995

Keywords

Circadian rhythm
Electrophysiology
Substance P
Suprachiasmatic nucleus
Tachykinin

Cite this

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title = "Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons",

abstract = "Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. {\textcopyright} 1995.",

keywords = "Circadian rhythm, Electrophysiology, Substance P, Suprachiasmatic nucleus, Tachykinin",

author = "Piggins, {Hugh D.} and Cutler, {David J.} and Benjamin Rusak",

year = "1995",

language = "English",

volume = "37",

pages = "475--479",

journal = "Brain Research Bulletin",

issn = "0361-9230",

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TY - JOUR

T1 - Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

AU - Piggins, Hugh D.

AU - Cutler, David J.

AU - Rusak, Benjamin

PY - 1995

Y1 - 1995

N2 - Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. © 1995.

AB - Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. © 1995.

KW - Circadian rhythm

KW - Electrophysiology

KW - Substance P

KW - Suprachiasmatic nucleus

KW - Tachykinin

M3 - Article

C2 - 0007543357

SN - 0361-9230

VL - 37

SP - 475

EP - 479

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 5

ER -

Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

Abstract

Keywords

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