IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. A controlled cohort study

Gus A Baker, Rebecca L Bromley, Maria Briggs, Christopher P Cheyne, Morris J Cohen, Marta García-Fiñana, Alison Gummery, Rachel Kneen, David W Loring, George Mawer, Kimford J Meador, Rebekah Shallcross, Jill Clayton-Smith

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Abstract

OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and followed prospectively. Of these, 408 were blindly assessed at 6 years of age. Maternal and child demographics were collected and entered into statistical models. RESULTS: The adjusted mean IQ was 9.7 points lower (95% confidence interval [CI] -4.9 to -14.6; p <0.001) for children exposed to high-dose (>800 mg daily) valproate, with a similar significant effect observed for the verbal, nonverbal, and spatial subscales. Children exposed to high-dose valproate had an 8-fold increased need of educational intervention relative to control children (adjusted relative risk, 95% CI 8.0, 2.5-19.7; p <0.001). Valproate at doses
Original languageEnglish
Pages (from-to)382-390
Number of pages8
JournalNeurology
Volume84
Issue number4
DOIs
Publication statusPublished - 27 Jan 2015

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