Abstract
OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and followed prospectively. Of these, 408 were blindly assessed at 6 years of age. Maternal and child demographics were collected and entered into statistical models. RESULTS: The adjusted mean IQ was 9.7 points lower (95% confidence interval [CI] -4.9 to -14.6; p <0.001) for children exposed to high-dose (>800 mg daily) valproate, with a similar significant effect observed for the verbal, nonverbal, and spatial subscales. Children exposed to high-dose valproate had an 8-fold increased need of educational intervention relative to control children (adjusted relative risk, 95% CI 8.0, 2.5-19.7; p <0.001). Valproate at doses
Original language | English |
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Pages (from-to) | 382-390 |
Number of pages | 8 |
Journal | Neurology |
Volume | 84 |
Issue number | 4 |
DOIs | |
Publication status | Published - 27 Jan 2015 |
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Dive into the research topics of 'IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. A controlled cohort study'. Together they form a unique fingerprint.Impacts
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Worldwide reduction in the number of children exposed to harmful antiepileptic drugs in the womb
Bromley, R. (Participant) & (Participant)
Impact: Health and wellbeing, Policy