TY - JOUR
T1 - Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection?
T2 - A Retrospective Study
AU - Chatterjee, Tulika
AU - Bansal, Saurabh
AU - Abuzar, Asif
AU - Hussain, Habiba
AU - Gupta, Latika
N1 - © 2022 Greater Baltimore Medical Center.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile.HYPOTHESIS: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI).METHODS: Data was collected by retrospective chart query. Severe CDI was defined as a white blood cell count of more than 15,000 (x 109 cells/L) or serum creatinine levels greater than 1.5 mg/dL. To examine the association between the primary outcome (severe CDI) and BMI, the factors of age, gender, albumin level, ICU admission, antibiotic use within 3 months of admission, diabetes, and hypertension were also considered. Patients with chronic kidney disease, end-stage liver disease, pregnancy, inflammatory bowel disease, previous gastrointestinal surgeries, active malignancy, and immunosuppressed were excluded.RESULTS: 219 patients were included in the final study. Of these 52.8% of patients had severe CDI, and 47.2% had non-severe CDI. Compared to normal-weight patients, risk of severe CDI was not influenced by being obese (OR = 1.26, p = 0.5119), overweight (OR = 1.65, p = 0.21), or underweight (OR = 1.05, p = 0.9383). Males had higher odds of having severe CDI when compared with females (OR = 1.76, 95% CI = 1.03 to 3.01, p = 0.0395). Albumin levels greater than 3.0 mg/dL were associated with lower odds of having severe CDI (OR = 0.41, 95% CI = 0.27 to 0.62, p< 0.0001).CONCLUSION: BMI of an individual does not appear to be associated with the severity of CDI.
AB - BACKGROUND: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile.HYPOTHESIS: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI).METHODS: Data was collected by retrospective chart query. Severe CDI was defined as a white blood cell count of more than 15,000 (x 109 cells/L) or serum creatinine levels greater than 1.5 mg/dL. To examine the association between the primary outcome (severe CDI) and BMI, the factors of age, gender, albumin level, ICU admission, antibiotic use within 3 months of admission, diabetes, and hypertension were also considered. Patients with chronic kidney disease, end-stage liver disease, pregnancy, inflammatory bowel disease, previous gastrointestinal surgeries, active malignancy, and immunosuppressed were excluded.RESULTS: 219 patients were included in the final study. Of these 52.8% of patients had severe CDI, and 47.2% had non-severe CDI. Compared to normal-weight patients, risk of severe CDI was not influenced by being obese (OR = 1.26, p = 0.5119), overweight (OR = 1.65, p = 0.21), or underweight (OR = 1.05, p = 0.9383). Males had higher odds of having severe CDI when compared with females (OR = 1.76, 95% CI = 1.03 to 3.01, p = 0.0395). Albumin levels greater than 3.0 mg/dL were associated with lower odds of having severe CDI (OR = 0.41, 95% CI = 0.27 to 0.62, p< 0.0001).CONCLUSION: BMI of an individual does not appear to be associated with the severity of CDI.
U2 - 10.55729/2000-9666.1123
DO - 10.55729/2000-9666.1123
M3 - Article
C2 - 36816160
SN - 2000-9666
VL - 12
SP - 43
EP - 50
JO - Journal of community hospital internal medicine perspectives
JF - Journal of community hospital internal medicine perspectives
IS - 6
ER -