Is paraoxonase related to atherosclerosis

Michael I. Mackness; Sharon Arrol; Caroline A. Abbott; Paul N. Durrington

Is paraoxonase related to atherosclerosis

Michael I. Mackness, Sharon Arrol, Caroline A. Abbott, Paul N. Durrington

Research output: Contribution to journal › Article › peer-review

Abstract

Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physisological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and atherosclerosis. Paraoxonase may a fundamental role in lipoprotein metabolism, preventing oxidative changes to low-density lipoprotein which render the particle atherogenic. © 1993.

Original language	English
Pages (from-to)	161-171
Number of pages	10
Journal	Chemico-Biological Interactions
Volume	87
Issue number	1-3
Publication status	Published - Jun 1993

Keywords

Atherosclerosis
High-density lipoprotein
Low-density lipoprotein
Oxidation
Paraoxonase

Cite this

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title = "Is paraoxonase related to atherosclerosis",

abstract = "Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physisological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and atherosclerosis. Paraoxonase may a fundamental role in lipoprotein metabolism, preventing oxidative changes to low-density lipoprotein which render the particle atherogenic. {\textcopyright} 1993.",

keywords = "Atherosclerosis, High-density lipoprotein, Low-density lipoprotein, Oxidation, Paraoxonase",

author = "Mackness, {Michael I.} and Sharon Arrol and Abbott, {Caroline A.} and Durrington, {Paul N.}",

year = "1993",

month = jun,

language = "English",

volume = "87",

pages = "161--171",

journal = "Chemico-Biological Interactions",

issn = "0009-2797",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Is paraoxonase related to atherosclerosis

AU - Mackness, Michael I.

AU - Arrol, Sharon

AU - Abbott, Caroline A.

AU - Durrington, Paul N.

PY - 1993/6

Y1 - 1993/6

N2 - Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physisological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and atherosclerosis. Paraoxonase may a fundamental role in lipoprotein metabolism, preventing oxidative changes to low-density lipoprotein which render the particle atherogenic. © 1993.

AB - Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physisological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and atherosclerosis. Paraoxonase may a fundamental role in lipoprotein metabolism, preventing oxidative changes to low-density lipoprotein which render the particle atherogenic. © 1993.

KW - Atherosclerosis

KW - High-density lipoprotein

KW - Low-density lipoprotein

KW - Oxidation

KW - Paraoxonase

M3 - Article

SN - 0009-2797

VL - 87

SP - 161

EP - 171

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

IS - 1-3

ER -

Is paraoxonase related to atherosclerosis

Abstract

Keywords

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