Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure

S. Withers; M. Taggart; C. Austin

doi:10.1016/j.placenta.2012.11.004

Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure

S. Withers, M. Taggart, C. Austin

Research output: Contribution to journal › Article › peer-review

Abstract

An adequate blood supply is essential for the maintenance of uterine function and fetal health during parturition. However, labouring uterine contractions will impart compressive forces on small uterine arteries (SUA). We demonstrate that isolated, pressurised rat SUA arteries, pre-constricted with arginine vasopressin or high potassium solution, exhibit regulatory responses to elevations in extravascular pressure (EVP) which maintain internal diameter constant at EVPs of 0-40 mm Hg. This response is endothelium independent and is not modulated by pregnancy. No regulation was observed in calcium free solution. SUA myogenic responses to elevated EVP likely represents a mechanism for limiting reductions in uterine blood flow during uterine contraction. © 2012 Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	82-84
Number of pages	2
Journal	Placenta
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.placenta.2012.11.004
Publication status	Published - Jan 2013

Keywords

Extravascular pressure
Myogenic responsiveness
Uterine artery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.placenta.2012.11.004

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abstract = "An adequate blood supply is essential for the maintenance of uterine function and fetal health during parturition. However, labouring uterine contractions will impart compressive forces on small uterine arteries (SUA). We demonstrate that isolated, pressurised rat SUA arteries, pre-constricted with arginine vasopressin or high potassium solution, exhibit regulatory responses to elevations in extravascular pressure (EVP) which maintain internal diameter constant at EVPs of 0-40 mm Hg. This response is endothelium independent and is not modulated by pregnancy. No regulation was observed in calcium free solution. SUA myogenic responses to elevated EVP likely represents a mechanism for limiting reductions in uterine blood flow during uterine contraction. {\textcopyright} 2012 Published by Elsevier Ltd. All rights reserved.",

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author = "S. Withers and M. Taggart and C. Austin",

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AU - Taggart, M.

AU - Austin, C.

PY - 2013/1

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N2 - An adequate blood supply is essential for the maintenance of uterine function and fetal health during parturition. However, labouring uterine contractions will impart compressive forces on small uterine arteries (SUA). We demonstrate that isolated, pressurised rat SUA arteries, pre-constricted with arginine vasopressin or high potassium solution, exhibit regulatory responses to elevations in extravascular pressure (EVP) which maintain internal diameter constant at EVPs of 0-40 mm Hg. This response is endothelium independent and is not modulated by pregnancy. No regulation was observed in calcium free solution. SUA myogenic responses to elevated EVP likely represents a mechanism for limiting reductions in uterine blood flow during uterine contraction. © 2012 Published by Elsevier Ltd. All rights reserved.

AB - An adequate blood supply is essential for the maintenance of uterine function and fetal health during parturition. However, labouring uterine contractions will impart compressive forces on small uterine arteries (SUA). We demonstrate that isolated, pressurised rat SUA arteries, pre-constricted with arginine vasopressin or high potassium solution, exhibit regulatory responses to elevations in extravascular pressure (EVP) which maintain internal diameter constant at EVPs of 0-40 mm Hg. This response is endothelium independent and is not modulated by pregnancy. No regulation was observed in calcium free solution. SUA myogenic responses to elevated EVP likely represents a mechanism for limiting reductions in uterine blood flow during uterine contraction. © 2012 Published by Elsevier Ltd. All rights reserved.

KW - Extravascular pressure

KW - Myogenic responsiveness

KW - Uterine artery

U2 - 10.1016/j.placenta.2012.11.004

DO - 10.1016/j.placenta.2012.11.004

M3 - Article

SN - 0143-4004

VL - 34

SP - 82

EP - 84

JO - Placenta

JF - Placenta

IS - 1

ER -

Isolated small uterine arteries from non-pregnant and term pregnant rats exhibit regulatory responses to elevations in extravascular pressure

Abstract

Keywords

UN SDGs

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