Isolates of Trichuris muris elicit different adaptive immune responses in their murine host

C. E. Johnston, J. E. Bradley, J. M. Behnke, K. R. Matthews, Kathryn J. Else

Research output: Contribution to journalArticlepeer-review

Abstract

The J and S isolates of Trichuris muris have different infection profiles in C57BL/6 mice; J worms are expelled, S worms survive to chronicity. Building on this, the ability of the J and S isolates to survive, and the quality of the immune response induced was explored in three different strains of mouse. The resistant BALB/c mouse mounted a strong Th2 response against both isolates, which were quickly expelled. The susceptible AKR host mounted a Th1 response and retained both isolates. Despite equivalent worm exposure, mesenteric lymph node cells from AKR mice infected with the S isolate produced significantly higher levels of IL-12 and the intestinal mastocytosis was reduced. IgG1 and IgG2a from S-infected AKR mice recognized low molecular weight antigens not recognized by J-infected mice. Differential expulsion kinetics was observed in the slower-responding C57BL/6 strain; J worms were expelled but S isolate worms were retained. Survival of the S isolate was again associated with elevated IL-12 and decreased Th2 responses. In resistant mouse strains, the outcome of infection is thus dominantly influenced by host genetics. However, in the slower-responding host, isolate-derived factors may play a role in shaping the quality of the adaptive immune response, thus influencing parasite survival. © 2005 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)69-78
Number of pages9
JournalParasite Immunology
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Differential T helper response
  • Excretory/secretory products
  • Intestinal nematode
  • Isolates

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