ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

M. J. Zamek-Gliszczynski; C. A. Lee; A. Poirier; J. Bentz; X. Chu; H. Ellens; T. Ishikawa; M. Jamei; J. C. Kalvass; S. Nagar; K. S. Pang; K. Korzekwa; P. W. Swaan; M. E. Taub; P. Zhao; A. Galetin

doi:10.1038/clpt.2013.45

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

M. J. Zamek-Gliszczynski, C. A. Lee, A. Poirier, J. Bentz, X. Chu, H. Ellens, T. Ishikawa, M. Jamei, J. C. Kalvass, S. Nagar, K. S. Pang, K. Korzekwa, P. W. Swaan, M. E. Taub, P. Zhao, A. Galetin

Research output: Contribution to journal › Article › peer-review

Abstract

This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro, in vivo, and modeling tools in translational transporter science. © 2013 American Society for Clinical Pharmacology and Therapeutics.

Original language	English
Pages (from-to)	64-79
Number of pages	15
Journal	Clinical Pharmacology and Therapeutics
Volume	94
Issue number	1
DOIs	https://doi.org/10.1038/clpt.2013.45
Publication status	Published - Jul 2013

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10.1038/clpt.2013.45

http://dx.doi.org/10.1038/clpt.2013.45

Modernising Drug Development Practices for Precision Dosing in Diverse Patient Populations
Amin Rostami-Hochaghan (Participant), Leon Aarons (Participant), Aleksandra Galetin (Participant), Jill Barber (Participant), Kayode Ogungbenro (Participant) & Adam Darwich (Participant)
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Zamek-Gliszczynski, M. J., Lee, C. A., Poirier, A., Bentz, J., Chu, X., Ellens, H., Ishikawa, T., Jamei, M., Kalvass, J. C., Nagar, S., Pang, K. S., Korzekwa, K., Swaan, P. W., Taub, M. E., Zhao, P., & Galetin, A. (2013). ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans. Clinical Pharmacology and Therapeutics, 94(1), 64-79. https://doi.org/10.1038/clpt.2013.45

@article{b48c148555254648b89ba5b07e0b85ea,

title = "ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans",

abstract = "This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro, in vivo, and modeling tools in translational transporter science. {\textcopyright} 2013 American Society for Clinical Pharmacology and Therapeutics.",

author = "Zamek-Gliszczynski, {M. J.} and Lee, {C. A.} and A. Poirier and J. Bentz and X. Chu and H. Ellens and T. Ishikawa and M. Jamei and Kalvass, {J. C.} and S. Nagar and Pang, {K. S.} and K. Korzekwa and Swaan, {P. W.} and Taub, {M. E.} and P. Zhao and A. Galetin",

year = "2013",

month = jul,

doi = "10.1038/clpt.2013.45",

language = "English",

volume = "94",

pages = "64--79",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "Springer Nature",

number = "1",

}

Zamek-Gliszczynski, MJ, Lee, CA, Poirier, A, Bentz, J, Chu, X, Ellens, H, Ishikawa, T, Jamei, M, Kalvass, JC, Nagar, S, Pang, KS, Korzekwa, K, Swaan, PW, Taub, ME, Zhao, P & Galetin, A 2013, 'ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans', Clinical Pharmacology and Therapeutics, vol. 94, no. 1, pp. 64-79. https://doi.org/10.1038/clpt.2013.45

TY - JOUR

T1 - ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

AU - Zamek-Gliszczynski, M. J.

AU - Lee, C. A.

AU - Poirier, A.

AU - Bentz, J.

AU - Chu, X.

AU - Ellens, H.

AU - Ishikawa, T.

AU - Jamei, M.

AU - Kalvass, J. C.

AU - Nagar, S.

AU - Pang, K. S.

AU - Korzekwa, K.

AU - Swaan, P. W.

AU - Taub, M. E.

AU - Zhao, P.

AU - Galetin, A.

PY - 2013/7

Y1 - 2013/7

N2 - This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro, in vivo, and modeling tools in translational transporter science. © 2013 American Society for Clinical Pharmacology and Therapeutics.

AB - This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro, in vivo, and modeling tools in translational transporter science. © 2013 American Society for Clinical Pharmacology and Therapeutics.

U2 - 10.1038/clpt.2013.45

DO - 10.1038/clpt.2013.45

M3 - Article

SN - 0009-9236

VL - 94

SP - 64

EP - 79

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 1

ER -

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

Abstract

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Modernising Drug Development Practices for Precision Dosing in Diverse Patient Populations

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