JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.

Michael P Lisanti; Aristotelis Tsirigos; Stephanos Pavlides; Kimberley Reeves; Maria Peiris Pages; Amy L Chadwick; Rosa Sanchez-Alvarez; Rebecca Lamb; Anthony Howell; Ubaldo E Martinez-Outschoorn; Federica Sotgia

doi:10.4161/cc.27379

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.

Michael P Lisanti, Aristotelis Tsirigos, Stephanos Pavlides, Kimberley Reeves, Maria Peiris Pages, Amy L Chadwick, Rosa Sanchez-Alvarez, Rebecca Lamb, Anthony Howell, Ubaldo E Martinez-Outschoorn, Federica Sotgia

Research output: Contribution to journal › Article › peer-review

Abstract

Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying this phenomenon remain largely unknown. Here, we re-interrogated genome-wide transcriptional profiling data obtained from low-density (LD) mammary fibroblasts (n = 6 patients) and high-density (HD) mammary fibroblasts (n = 7 patients) derived from a series of 13 female patients. We used these raw data to generate a "breast density" gene signature consisting of>1250 transcripts that were significantly increased in HD fibroblasts, relative to LD fibroblasts. We then focused on the genes that were increased by ≥ 1.5-fold (P

Original language	English
Pages (from-to)	580-599
Number of pages	19
Journal	Cell cycle (Georgetown, Tex.)
Volume	13
Issue number	4
Early online date	5 Dec 2013
DOIs	https://doi.org/10.4161/cc.27379
Publication status	Published - 15 Feb 2014

Keywords

EGF
FGF
JNK
PDGF
SAPK
TGF-beta
breast cancer
cancer associated fibroblasts
fibrosis
gene signature
inflammation
mammographic density
mammography
microenvironment
stress signaling
tumor stroma
wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.27379

https://www.landesbioscience.com/journals/cc/2013CC5423.pdf

Cite this

Lisanti, M. P., Tsirigos, A., Pavlides, S., Reeves, K., Peiris Pages, M., Chadwick, A. L., Sanchez-Alvarez, R., Lamb, R., Howell, A., Martinez-Outschoorn, U. E., & Sotgia, F. (2014). JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. Cell cycle (Georgetown, Tex.), 13(4), 580-599. https://doi.org/10.4161/cc.27379

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title = "JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.",

abstract = "Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying this phenomenon remain largely unknown. Here, we re-interrogated genome-wide transcriptional profiling data obtained from low-density (LD) mammary fibroblasts (n = 6 patients) and high-density (HD) mammary fibroblasts (n = 7 patients) derived from a series of 13 female patients. We used these raw data to generate a {"}breast density{"} gene signature consisting of>1250 transcripts that were significantly increased in HD fibroblasts, relative to LD fibroblasts. We then focused on the genes that were increased by ≥ 1.5-fold (P",

keywords = "EGF, FGF, JNK, PDGF, SAPK, TGF-beta, breast cancer, cancer associated fibroblasts, fibrosis, gene signature, inflammation, mammographic density, mammography, microenvironment, stress signaling, tumor stroma, wound healing",

author = "Lisanti, {Michael P} and Aristotelis Tsirigos and Stephanos Pavlides and Kimberley Reeves and {Peiris Pages}, Maria and Chadwick, {Amy L} and Rosa Sanchez-Alvarez and Rebecca Lamb and Anthony Howell and Martinez-Outschoorn, {Ubaldo E} and Federica Sotgia",

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Lisanti, MP, Tsirigos, A, Pavlides, S, Reeves, K, Peiris Pages, M, Chadwick, AL, Sanchez-Alvarez, R, Lamb, R, Howell, A, Martinez-Outschoorn, UE & Sotgia, F 2014, 'JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.', Cell cycle (Georgetown, Tex.), vol. 13, no. 4, pp. 580-599. https://doi.org/10.4161/cc.27379

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. / Lisanti, Michael P; Tsirigos, Aristotelis; Pavlides, Stephanos et al.

In: Cell cycle (Georgetown, Tex.), Vol. 13, No. 4, 15.02.2014, p. 580-599.

Research output: Contribution to journal › Article › peer-review

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AU - Lisanti, Michael P

AU - Tsirigos, Aristotelis

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AU - Reeves, Kimberley

AU - Peiris Pages, Maria

AU - Chadwick, Amy L

AU - Sanchez-Alvarez, Rosa

AU - Lamb, Rebecca

AU - Howell, Anthony

AU - Martinez-Outschoorn, Ubaldo E

AU - Sotgia, Federica

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AB - Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying this phenomenon remain largely unknown. Here, we re-interrogated genome-wide transcriptional profiling data obtained from low-density (LD) mammary fibroblasts (n = 6 patients) and high-density (HD) mammary fibroblasts (n = 7 patients) derived from a series of 13 female patients. We used these raw data to generate a "breast density" gene signature consisting of>1250 transcripts that were significantly increased in HD fibroblasts, relative to LD fibroblasts. We then focused on the genes that were increased by ≥ 1.5-fold (P

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KW - inflammation

KW - mammographic density

KW - mammography

KW - microenvironment

KW - stress signaling

KW - tumor stroma

KW - wound healing

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JF - Cell Cycle

SN - 1538-4101

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ER -

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.

Abstract

Keywords

UN SDGs

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