Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients

W. Thomson; J. H. Barrett; R. Donn; L. Pepper; L. J. Kennedy; W. E R Ollier; A. J S Silman; P. Woo; A. Bell; A. Craft; J. David; J. Griffin; A. Hall; M. Hall; A. Herrick; P. Hollingworth; L. Holt; S. Jones; G. Pountain; C. Ryder; T. Southwood; I. Stewart; S. Wyatt; H. Venning

Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients

W. Thomson, J. H. Barrett, R. Donn, L. Pepper, L. J. Kennedy, W. E R Ollier, A. J S Silman, P. Woo, A. Bell, A. Craft, J. David, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. Holt, S. Jones, G. Pountain, C. RyderT. Southwood, I. Stewart, S. Wyatt, H. Venning

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria. Methods. Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups. Results. Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups. Conclusion. This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.

Original language	English
Pages (from-to)	1183-1189
Number of pages	6
Journal	Rheumatology
Volume	41
Issue number	10
Publication status	Published - 1 Oct 2002

Keywords

HLA
JIA

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Thomson, W., Barrett, J. H., Donn, R., Pepper, L., Kennedy, L. J., Ollier, W. E. R., Silman, A. J. S., Woo, P., Bell, A., Craft, A., David, J., Griffin, J., Hall, A., Hall, M., Herrick, A., Hollingworth, P., Holt, L., Jones, S., Pountain, G., ... Venning, H. (2002). Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology, 41(10), 1183-1189.

@article{67b2e511d8f149359cd2897715c19681,

title = "Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients",

abstract = "Objective. To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria. Methods. Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups. Results. Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups. Conclusion. This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.",

keywords = "HLA, JIA",

author = "W. Thomson and Barrett, {J. H.} and R. Donn and L. Pepper and Kennedy, {L. J.} and Ollier, {W. E R} and Silman, {A. J S} and P. Woo and A. Bell and A. Craft and J. David and J. Griffin and A. Hall and M. Hall and A. Herrick and P. Hollingworth and L. Holt and S. Jones and G. Pountain and C. Ryder and T. Southwood and I. Stewart and S. Wyatt and H. Venning",

note = "UI - 22251286DA - 20021004IS - 1462-0324LA - engPT - Journal ArticleRN - 0 (HLA-B27 Antigen)RN - 0 (HLA-D Antigens)RN - 0 (HLA-DP Antigens)RN - 0 (HLA-DPB1)RN - 0 (HLA-DQ Antigens)RN - 0 (HLA-DR Antigens)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM",

year = "2002",

month = oct,

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language = "English",

volume = "41",

pages = "1183--1189",

journal = "Rheumatology",

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Thomson, W, Barrett, JH, Donn, R, Pepper, L, Kennedy, LJ , Ollier, WER, Silman, AJS, Woo, P, Bell, A, Craft, A, David, J, Griffin, J, Hall, A, Hall, M, Herrick, A, Hollingworth, P, Holt, L, Jones, S, Pountain, G, Ryder, C, Southwood, T, Stewart, I, Wyatt, S & Venning, H 2002, 'Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients', Rheumatology, vol. 41, no. 10, pp. 1183-1189.

TY - JOUR

T1 - Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients

AU - Thomson, W.

AU - Barrett, J. H.

AU - Donn, R.

AU - Pepper, L.

AU - Kennedy, L. J.

AU - Ollier, W. E R

AU - Silman, A. J S

AU - Woo, P.

AU - Bell, A.

AU - Craft, A.

AU - David, J.

AU - Griffin, J.

AU - Hall, A.

AU - Hall, M.

AU - Herrick, A.

AU - Hollingworth, P.

AU - Holt, L.

AU - Jones, S.

AU - Pountain, G.

AU - Ryder, C.

AU - Southwood, T.

AU - Stewart, I.

AU - Wyatt, S.

AU - Venning, H.

N1 - UI - 22251286DA - 20021004IS - 1462-0324LA - engPT - Journal ArticleRN - 0 (HLA-B27 Antigen)RN - 0 (HLA-D Antigens)RN - 0 (HLA-DP Antigens)RN - 0 (HLA-DPB1)RN - 0 (HLA-DQ Antigens)RN - 0 (HLA-DR Antigens)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Objective. To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria. Methods. Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups. Results. Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups. Conclusion. This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.

AB - Objective. To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria. Methods. Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups. Results. Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups. Conclusion. This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.

KW - HLA

KW - JIA

M3 - Article

SN - 1462-0332

VL - 41

SP - 1183

EP - 1189

JO - Rheumatology

JF - Rheumatology

IS - 10

ER -

Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients

Abstract

Keywords

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