Juvenile Reactive Arthritis and other Spondyloarthritides of Childhood: A 28-year Experience from India

Latika Gupta; R Naveen; Sakir Ahmed; Abhishek Zanwar; Durga P Misra; Able Lawrence; Vikas Agarwal; Ramnath Misra; Amita Aggarwal

doi:10.31138/mjr.32.4.338

Juvenile Reactive Arthritis and other Spondyloarthritides of Childhood: A 28-year Experience from India

Latika Gupta, R Naveen, Sakir Ahmed, Abhishek Zanwar, Durga P Misra, Able Lawrence, Vikas Agarwal, Ramnath Misra, Amita Aggarwal

Division of Musculoskeletal & Dermatological Sciences (L5)

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Understanding of Juvenile reactive arthritis (jReA) and other spondyloarthritides of childhood (jSpA) is limited to small case series. Since most of them have speculated pathogenic origins in the gut, we compared and contrasted jReA with other jSpA -Enthesitis-related arthritis (ERA) and undifferentiated SpA (jUSpA).

METHODS: A record-based medical data review of jReA, and jUSpA was compared with cohort data of ERA collected for other studies. Data are presented as median (interquartile range) and non-parametric tests used for analysis.

RESULTS: Of 179 juvenile SpA (61 jReA; 101 ERA; and 17 jUSpA), 61 had jReA [M:F-52:9; 15.5 (12-18) years] with a disease duration of 2.75(1-36) months. Inflammatory backache IBP (32%), dactylitis (21%) and enthesitis (29%) were common. A significant proportion (14 of 17, 82.3% at >6 months follow-up) had a chronic course. 101 ERA [M:F-93:7; age-16(14-20) years] had a longer disease duration (45 vs 2.75 months, p<0.001), as compared with jReA. Enthesitis and IBP was more common in ERA (OR-2.3 and 3.4 respectively). jUSpA (n=17) had a similar clinico-laboratory profile and exhibited significant (7 of 17, 58.3%) chronicity over 9.5(4.8-37) months follow-up.

CONCLUSION: jReA and jSpA exhibit similar features apart from varying disease duration, suggesting that jspA may form a continuum with similar clinico-laboratory profiles plausibly due to shared pathogenesis.

Original language	English
Pages (from-to)	338-344
Number of pages	7
Journal	Mediterranean journal of rheumatology
Volume	32
Issue number	4
DOIs	https://doi.org/10.31138/mjr.32.4.338
Publication status	Published - Dec 2021

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@article{dc22721534d243d9971e54acb576393a,

title = "Juvenile Reactive Arthritis and other Spondyloarthritides of Childhood: A 28-year Experience from India",

abstract = "OBJECTIVES: Understanding of Juvenile reactive arthritis (jReA) and other spondyloarthritides of childhood (jSpA) is limited to small case series. Since most of them have speculated pathogenic origins in the gut, we compared and contrasted jReA with other jSpA -Enthesitis-related arthritis (ERA) and undifferentiated SpA (jUSpA).METHODS: A record-based medical data review of jReA, and jUSpA was compared with cohort data of ERA collected for other studies. Data are presented as median (interquartile range) and non-parametric tests used for analysis.RESULTS: Of 179 juvenile SpA (61 jReA; 101 ERA; and 17 jUSpA), 61 had jReA [M:F-52:9; 15.5 (12-18) years] with a disease duration of 2.75(1-36) months. Inflammatory backache IBP (32%), dactylitis (21%) and enthesitis (29%) were common. A significant proportion (14 of 17, 82.3% at >6 months follow-up) had a chronic course. 101 ERA [M:F-93:7; age-16(14-20) years] had a longer disease duration (45 vs 2.75 months, p<0.001), as compared with jReA. Enthesitis and IBP was more common in ERA (OR-2.3 and 3.4 respectively). jUSpA (n=17) had a similar clinico-laboratory profile and exhibited significant (7 of 17, 58.3%) chronicity over 9.5(4.8-37) months follow-up.CONCLUSION: jReA and jSpA exhibit similar features apart from varying disease duration, suggesting that jspA may form a continuum with similar clinico-laboratory profiles plausibly due to shared pathogenesis.",

author = "Latika Gupta and R Naveen and Sakir Ahmed and Abhishek Zanwar and Misra, {Durga P} and Able Lawrence and Vikas Agarwal and Ramnath Misra and Amita Aggarwal",

note = "{\textcopyright} 2021 The Mediterranean Journal of Rheumatology (MJR).",

year = "2021",

month = dec,

doi = "10.31138/mjr.32.4.338",

language = "English",

volume = "32",

pages = "338--344",

journal = "Mediterranean journal of rheumatology",

issn = "2529-198X",

publisher = "Greek Rheumatology Society and Professional Association of Rheumatologists",

number = "4",

}

TY - JOUR

T1 - Juvenile Reactive Arthritis and other Spondyloarthritides of Childhood

T2 - A 28-year Experience from India

AU - Gupta, Latika

AU - Naveen, R

AU - Ahmed, Sakir

AU - Zanwar, Abhishek

AU - Misra, Durga P

AU - Lawrence, Able

AU - Agarwal, Vikas

AU - Misra, Ramnath

AU - Aggarwal, Amita

PY - 2021/12

Y1 - 2021/12

N2 - OBJECTIVES: Understanding of Juvenile reactive arthritis (jReA) and other spondyloarthritides of childhood (jSpA) is limited to small case series. Since most of them have speculated pathogenic origins in the gut, we compared and contrasted jReA with other jSpA -Enthesitis-related arthritis (ERA) and undifferentiated SpA (jUSpA).METHODS: A record-based medical data review of jReA, and jUSpA was compared with cohort data of ERA collected for other studies. Data are presented as median (interquartile range) and non-parametric tests used for analysis.RESULTS: Of 179 juvenile SpA (61 jReA; 101 ERA; and 17 jUSpA), 61 had jReA [M:F-52:9; 15.5 (12-18) years] with a disease duration of 2.75(1-36) months. Inflammatory backache IBP (32%), dactylitis (21%) and enthesitis (29%) were common. A significant proportion (14 of 17, 82.3% at >6 months follow-up) had a chronic course. 101 ERA [M:F-93:7; age-16(14-20) years] had a longer disease duration (45 vs 2.75 months, p<0.001), as compared with jReA. Enthesitis and IBP was more common in ERA (OR-2.3 and 3.4 respectively). jUSpA (n=17) had a similar clinico-laboratory profile and exhibited significant (7 of 17, 58.3%) chronicity over 9.5(4.8-37) months follow-up.CONCLUSION: jReA and jSpA exhibit similar features apart from varying disease duration, suggesting that jspA may form a continuum with similar clinico-laboratory profiles plausibly due to shared pathogenesis.

AB - OBJECTIVES: Understanding of Juvenile reactive arthritis (jReA) and other spondyloarthritides of childhood (jSpA) is limited to small case series. Since most of them have speculated pathogenic origins in the gut, we compared and contrasted jReA with other jSpA -Enthesitis-related arthritis (ERA) and undifferentiated SpA (jUSpA).METHODS: A record-based medical data review of jReA, and jUSpA was compared with cohort data of ERA collected for other studies. Data are presented as median (interquartile range) and non-parametric tests used for analysis.RESULTS: Of 179 juvenile SpA (61 jReA; 101 ERA; and 17 jUSpA), 61 had jReA [M:F-52:9; 15.5 (12-18) years] with a disease duration of 2.75(1-36) months. Inflammatory backache IBP (32%), dactylitis (21%) and enthesitis (29%) were common. A significant proportion (14 of 17, 82.3% at >6 months follow-up) had a chronic course. 101 ERA [M:F-93:7; age-16(14-20) years] had a longer disease duration (45 vs 2.75 months, p<0.001), as compared with jReA. Enthesitis and IBP was more common in ERA (OR-2.3 and 3.4 respectively). jUSpA (n=17) had a similar clinico-laboratory profile and exhibited significant (7 of 17, 58.3%) chronicity over 9.5(4.8-37) months follow-up.CONCLUSION: jReA and jSpA exhibit similar features apart from varying disease duration, suggesting that jspA may form a continuum with similar clinico-laboratory profiles plausibly due to shared pathogenesis.

U2 - 10.31138/mjr.32.4.338

DO - 10.31138/mjr.32.4.338

M3 - Article

C2 - 35128326

SN - 2529-198X

VL - 32

SP - 338

EP - 344

JO - Mediterranean journal of rheumatology

JF - Mediterranean journal of rheumatology

IS - 4

ER -

Juvenile Reactive Arthritis and other Spondyloarthritides of Childhood: A 28-year Experience from India

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