Keratinocytes derived from late-onset psoriasis skin do not impair Langerhans cell migration

L H Eaton, R J Dearman, I Kimber, C E M Griffiths

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Chronic plaque psoriasis (CPP) is associated with over-expression of interleukin (IL)-17 and systemic antibody therapies targeting this cytokine are highly efficacious1 . Psoriasis presents as either early- or late-onset disease (before or after 40 years of age, respectively). Langerhans cells (LC) are the dendritic cells of the epidermis that regulate cutaneous immune responses2 . In the uninvolved skin of early-onset CPP there is impaired LC migration after exposure to a contact allergen, tumour necrosis factor-α (TNF-α) or IL-1β in vivo3 . However, in late-onset psoriasis there is impaired migration in response to TNF-α, but normal responses to IL-1β4 . We have recently shown that in early-onset psoriasis, LC migration is impaired as a result of IL-17A causing changes in the psoriasis keratinocyte secretome5 . Here we sought to examine whether keratinocytes isolated from uninvolved late-onset psoriasis skin also impair LC migration. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)1208-1209
JournalThe British journal of dermatology
Issue number5
Early online date19 Jun 2018
Publication statusPublished - Nov 2018


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