Abstract
In isolated, cultured neonatal rat ventricular myocytes sodium currents through calcium channels induced by lowering of extracellular calcium concentration 100 nmol/l have been investigated by whole-cell patch clamp technique. Such Na(+)-carried currents are modulated by classic Ca2+ agonists and antagonists. The potential-dependent characteristics of Na+ current are shifted at 20 mV in hyperpolarizing direction as compared to initial Ca(2+)-carried current. The inactivation decay of Na+ current through Ca2+ channels has the monoexponential behaviour. The possible action of extracellular Ca2+ lowering on Ca2+ channel selective filter and gating mechanisms is suggested.
| Translated title of the contribution | The characteristics of the sodium currents across EGTA-modified calcium channels in the membrane of cultured rat cardiomyocytes |
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| Original language | Russian |
| Pages (from-to) | 49-53 |
| Number of pages | 4 |
| Journal | Fiziolohichnyi zhurnal |
| Volume | 37 |
| Issue number | 2 |
| Publication status | Published - Mar 1991 |