Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis

M. M. Amoli, E. Shelley, D. L. Mattey, C. Garcia-Porrua, W. Thomson, A. H. Hajeer, W. E R Ollier, M. A. Gonzalez-Gay

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    Objective. Studies have shown an association between HLA-DRB1*04 and giant cell arteritis (GCA). Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms were reported to contribute susceptibility to GCA in Italian patients where susceptibility to GCA is not associated with HLA-DRB1*04 alleles. ICAM-1 is also highly expressed within inflammatory infiltrates of the blood vessels of GCA patients. To investigate the clinical implications of ICAM-1 polymorphisms in GCA, we examined their potential association and influence in the development of visual ischemic complications in a series of patients with GCA from Northwest Spain where GCA susceptibility is associated with HLA-DRB1*04. Methods. Fifty-eight biopsy proven GCA and 129 ethnically matched controls were studied. Patients and controls were genotyped for ICAM-1 polymorphism at codons 241 and 469 by PCR-RFLP. Results. The distribution of the alleles and genotypes for each ICAM-1 polymorphism did not show significant differences between GCA patients and controls. Although visual manifestations were significantly more likely to occur in men than women (OR 5.2, p = 0.018), allele and genotype frequencies of ICAM-1 polymorphisms in patients with GCA were not associated with development of visual complications or anemia. Visual complications in GCA were primarily associated with carriage of an HLA-DRB1*04 allele. No evidence was found for interaction between HLA-DRB1*04 and ICAM-1 polymorphism. Conclusion. ICAM-1 polymorphisms are not genetic risk factors for the susceptibility and severity of GCA in Northwest Spain.
    Original languageEnglish
    Pages (from-to)1600-1604
    Number of pages4
    JournalJournal of Rheumatology
    Issue number7
    Publication statusPublished - 2001


    • Disease susceptibility
    • Giant cell (temporal) arteritis
    • HLA-DRB1
    • Intercellular adhesion molecule-1
    • Visual complications


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