TY - JOUR
T1 - Lack of association between polymorphisms of thrombogenic genes and disease susceptibility in rheumatoid arthritis
AU - Dimitroulas, Theodoros
AU - Douglas, Karen M J
AU - Smith, Jacqueline
AU - Panoulas, Vasilis F.
AU - Kitas, George D.
PY - 2013/9
Y1 - 2013/9
N2 - Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Abnormalities in coagulation have been linked with CVD in general and RA population. The aim of our study is to determine whether particular single nucleotide polymorphisms thought to be involved in the regulation of coagulation are over-represented in patients with RA compared to controls. We compared the frequency of atherothrombotic polymorphisms (Factor V Leiden, fibrinogen G455A, prothrombin G20210A and plasminogen activator inhibitor 4G5G) in 322 RA patients [231 females, mean age 61.5 ± 12, median disease duration 10 years (IQR = 14)] with 441 local controls. No significant differences were observed in genotype or allele frequencies either between RA and controls or between the disease subgroups studied. Whereas these polymorphisms may be of importance at the level of individual patients, they are unlikely to be clinically important on a population basis. © 2012 Springer-Verlag.
AB - Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Abnormalities in coagulation have been linked with CVD in general and RA population. The aim of our study is to determine whether particular single nucleotide polymorphisms thought to be involved in the regulation of coagulation are over-represented in patients with RA compared to controls. We compared the frequency of atherothrombotic polymorphisms (Factor V Leiden, fibrinogen G455A, prothrombin G20210A and plasminogen activator inhibitor 4G5G) in 322 RA patients [231 females, mean age 61.5 ± 12, median disease duration 10 years (IQR = 14)] with 441 local controls. No significant differences were observed in genotype or allele frequencies either between RA and controls or between the disease subgroups studied. Whereas these polymorphisms may be of importance at the level of individual patients, they are unlikely to be clinically important on a population basis. © 2012 Springer-Verlag.
KW - Atherothrombosis
KW - Cardiovascular disease
KW - Genetic polymorphism
KW - Rheumatoid arthritis
U2 - 10.1007/s00296-012-2392-6
DO - 10.1007/s00296-012-2392-6
M3 - Article
C2 - 22466403
SN - 0172-8172
VL - 33
SP - 2429
EP - 2432
JO - Rheumatology International
JF - Rheumatology International
IS - 9
ER -
