Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs

J. Worthington; A. S. Rigby; A. J. MacGregor; A. J. Silman; D. Carthy; W. E R Ollier

doi:10.1136/ard.52.7.542

Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs

J. Worthington, A. S. Rigby, A. J. MacGregor, A. J. Silman, D. Carthy, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives-To investigate the role of humoral immunity to mycobacterial hsp65 in the aetiology of rheumatoid arthritis. Methods-Levels of IgG antibodies to recombinant mycobacterial hsp65 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples of 152 twin pairs discordant for RA and in serum samples from 62 normal blood donors. Results-No significant differences between antibody levels in the subjects with RA compared either with their unaffected twins or with a group ofnormal blood donors was observed. In the monozygotic twins there was a strong but negative association between levels of antibody to hsp65 and disease status. Zygosity, sex, and HLA status did not significantly affect levels of antibody to hsp65. Conclusion-Previous reports of an association between hsp65 and RA were not confirmed.

Original language	English
Pages (from-to)	542-544
Number of pages	2
Journal	Annals of the rheumatic diseases
Volume	52
Issue number	7
DOIs	https://doi.org/10.1136/ard.52.7.542
Publication status	Published - 1993

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

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10.1136/ard.52.7.542

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@article{83d0d39c7a3e498095ca140ecb528068,

title = "Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs",

abstract = "Objectives-To investigate the role of humoral immunity to mycobacterial hsp65 in the aetiology of rheumatoid arthritis. Methods-Levels of IgG antibodies to recombinant mycobacterial hsp65 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples of 152 twin pairs discordant for RA and in serum samples from 62 normal blood donors. Results-No significant differences between antibody levels in the subjects with RA compared either with their unaffected twins or with a group ofnormal blood donors was observed. In the monozygotic twins there was a strong but negative association between levels of antibody to hsp65 and disease status. Zygosity, sex, and HLA status did not significantly affect levels of antibody to hsp65. Conclusion-Previous reports of an association between hsp65 and RA were not confirmed.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "J. Worthington and Rigby, {A. S.} and MacGregor, {A. J.} and Silman, {A. J.} and D. Carthy and Ollier, {W. E R}",

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year = "1993",

doi = "10.1136/ard.52.7.542",

language = "English",

volume = "52",

pages = "542--544",

journal = "Annals of the rheumatic diseases",

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TY - JOUR

T1 - Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs

AU - Worthington, J.

AU - Rigby, A. S.

AU - MacGregor, A. J.

AU - Silman, A. J.

AU - Carthy, D.

AU - Ollier, W. E R

N1 - UI - 93349138 LA - eng RN - 0 (Antibodies, Bacterial) RN - 0 (Heat-Shock Proteins) RN - 0 (Immunoglobulin G) RN - 0 (heat-shock protein 65) PT - Journal Article DA - 19930909 IS - 0003-4967 SB - IM CY - ENGLAND

PY - 1993

Y1 - 1993

N2 - Objectives-To investigate the role of humoral immunity to mycobacterial hsp65 in the aetiology of rheumatoid arthritis. Methods-Levels of IgG antibodies to recombinant mycobacterial hsp65 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples of 152 twin pairs discordant for RA and in serum samples from 62 normal blood donors. Results-No significant differences between antibody levels in the subjects with RA compared either with their unaffected twins or with a group ofnormal blood donors was observed. In the monozygotic twins there was a strong but negative association between levels of antibody to hsp65 and disease status. Zygosity, sex, and HLA status did not significantly affect levels of antibody to hsp65. Conclusion-Previous reports of an association between hsp65 and RA were not confirmed.

AB - Objectives-To investigate the role of humoral immunity to mycobacterial hsp65 in the aetiology of rheumatoid arthritis. Methods-Levels of IgG antibodies to recombinant mycobacterial hsp65 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples of 152 twin pairs discordant for RA and in serum samples from 62 normal blood donors. Results-No significant differences between antibody levels in the subjects with RA compared either with their unaffected twins or with a group ofnormal blood donors was observed. In the monozygotic twins there was a strong but negative association between levels of antibody to hsp65 and disease status. Zygosity, sex, and HLA status did not significantly affect levels of antibody to hsp65. Conclusion-Previous reports of an association between hsp65 and RA were not confirmed.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

U2 - 10.1136/ard.52.7.542

DO - 10.1136/ard.52.7.542

M3 - Article

SN - 0003-4967

VL - 52

SP - 542

EP - 544

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 7

ER -

Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs

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