Langerhans cell migration: Not necessarily always at the center of the skin sensitization universe

Ian Kimber; Marie Cumberbatch; Rebecca J. Dearman

doi:10.1038/jid.2009.54

Langerhans cell migration: Not necessarily always at the center of the skin sensitization universe

Ian Kimber, Marie Cumberbatch, Rebecca J. Dearman

Research output: Contribution to journal › Article › peer-review

Abstract

Since their discovery in 1868, the role of Langerhans cells (LCs) in skin immunity has been researched extensively. Recent data deriving from transgenic animals that are deficient in LCs have begun to challenge the dogma that there is a universal requirement for these cells in the development of skin sensitization. This Commentary addresses relationships between LC mobilization, draining lymph node activation, and skin sensitization using immunomodulators agonistic for a family of sphingosine-1-phosphate (S1P) receptors. © 2009 The Society for Investigative Dermatology.

Original language	English
Pages (from-to)	1852-1853
Number of pages	1
Journal	Journal of Investigative Dermatology
Volume	129
Issue number	8
DOIs	https://doi.org/10.1038/jid.2009.54
Publication status	Published - Aug 2009

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title = "Langerhans cell migration: Not necessarily always at the center of the skin sensitization universe",

abstract = "Since their discovery in 1868, the role of Langerhans cells (LCs) in skin immunity has been researched extensively. Recent data deriving from transgenic animals that are deficient in LCs have begun to challenge the dogma that there is a universal requirement for these cells in the development of skin sensitization. This Commentary addresses relationships between LC mobilization, draining lymph node activation, and skin sensitization using immunomodulators agonistic for a family of sphingosine-1-phosphate (S1P) receptors. {\textcopyright} 2009 The Society for Investigative Dermatology.",

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AB - Since their discovery in 1868, the role of Langerhans cells (LCs) in skin immunity has been researched extensively. Recent data deriving from transgenic animals that are deficient in LCs have begun to challenge the dogma that there is a universal requirement for these cells in the development of skin sensitization. This Commentary addresses relationships between LC mobilization, draining lymph node activation, and skin sensitization using immunomodulators agonistic for a family of sphingosine-1-phosphate (S1P) receptors. © 2009 The Society for Investigative Dermatology.

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Langerhans cell migration: Not necessarily always at the center of the skin sensitization universe

Abstract

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