Langerhans cells express human beta defensin-3: relevance for immunity during skin ageing

S M Pilkington; R J Dearman; I Kimber; C E M Griffiths

doi:10.1111/bjd.16770

Langerhans cells express human beta defensin-3: relevance for immunity during skin ageing

S M Pilkington, R J Dearman, I Kimber, C E M Griffiths

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Abstract

Ageing and immunosenescence are associated with an increased susceptibility to skin infections and skin cancers. Epidermal Langerhans cells (LC) survey the skin microenvironment for pathogens and tumour cells and migrate to lymph nodes to present antigen. In humans there are fewer epidermal LC in aged as compared with young skin and their migration is reduced in response to trauma and tumour necrosis factor (TNF)-α. We have also shown that interleukin (IL)-1β gene expression is reduced in aged skin and that LC migration is restored by exogenous IL-1β. This article is protected by copyright. All rights reserved.

Original language	English
Journal	The British journal of dermatology
Early online date	14 May 2018
DOIs	https://doi.org/10.1111/bjd.16770
Publication status	Published - 2018

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Embargo ends: 1/01/28

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title = "Langerhans cells express human beta defensin-3: relevance for immunity during skin ageing",

abstract = "Ageing and immunosenescence are associated with an increased susceptibility to skin infections and skin cancers. Epidermal Langerhans cells (LC) survey the skin microenvironment for pathogens and tumour cells and migrate to lymph nodes to present antigen. In humans there are fewer epidermal LC in aged as compared with young skin and their migration is reduced in response to trauma and tumour necrosis factor (TNF)-α. We have also shown that interleukin (IL)-1β gene expression is reduced in aged skin and that LC migration is restored by exogenous IL-1β. This article is protected by copyright. All rights reserved.",

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AU - Kimber, I

AU - Griffiths, C E M

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AB - Ageing and immunosenescence are associated with an increased susceptibility to skin infections and skin cancers. Epidermal Langerhans cells (LC) survey the skin microenvironment for pathogens and tumour cells and migrate to lymph nodes to present antigen. In humans there are fewer epidermal LC in aged as compared with young skin and their migration is reduced in response to trauma and tumour necrosis factor (TNF)-α. We have also shown that interleukin (IL)-1β gene expression is reduced in aged skin and that LC migration is restored by exogenous IL-1β. This article is protected by copyright. All rights reserved.

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DO - 10.1111/bjd.16770

M3 - Article

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JO - The British journal of dermatology

JF - The British journal of dermatology

ER -

Langerhans cells express human beta defensin-3: relevance for immunity during skin ageing

Abstract

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