Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists

Colin R Lindsay, Emily C Shaw, David A Moore, Doris Rassl, Mariam Jamal-Hanjani, Nicola Steele, Salma Naheed, Craig Dick, Fiona Taylor, Helen Adderley, Fiona Black, Yvonne Summers, Matt Evans, Alexandra Rice, Aurelie Fabre, William A Wallace, Siobhan Nicholson, Alex Haragan, Phillipe Taniere, Andrew G NicholsonGavin Laing, Judith Cave, Martin D Forster, Fiona Blackhall, John Gosney, Sanjay Popat, Keith M Kerr

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the past 10 years, lung cancer clinical and translational research has been characterised by exponential progress, exemplified by the introduction of molecularly targeted therapies, immunotherapy and chemo-immunotherapy combinations to stage III and IV non-small cell lung cancer. Along with squamous and small cell lung cancers, large cell neuroendocrine carcinoma (LCNEC) now represents an area of unmet need, particularly hampered by the lack of an encompassing pathological definition that can facilitate real-world and clinical trial progress. The steps we have proposed in this article represent an iterative and rational path forward towards clinical breakthroughs that can be modelled on success in other lung cancer pathologies.

Original languageEnglish
Pages (from-to)1210-1216
Number of pages7
JournalBritish Journal of Cancer
Volume125
Issue number9
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Biomarkers, Tumor/metabolism
  • Carcinoma, Large Cell/metabolism
  • Carcinoma, Neuroendocrine/metabolism
  • Clinical Trials as Topic
  • Consensus
  • Humans
  • Lung Neoplasms/metabolism
  • Precision Medicine
  • Treatment Outcome

Fingerprint

Dive into the research topics of 'Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists'. Together they form a unique fingerprint.

Cite this