Abstract
| Original language | English |
|---|---|
| Journal | PL o S Genetics |
| Volume | 7 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2011 |
Access to Document
Fingerprint
Dive into the research topics of 'Large-scale gene-centric analysis identifies novel variants for coronary artery disease.'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: PL o S Genetics, Vol. 7, No. 9, 09.2011.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
A2 - Butterworth, Adam S
A2 - Farrall, Martin
A2 - Hardwick, Robert J
A2 - Saleheen, Danish
A2 - Soranzo, Nicole
A2 - Chambers, John C
A2 - Sivapalaratnam, Suthesh
A2 - Kleber, Marcus E
A2 - Keating, Brendan
A2 - Qasim, Atif
A2 - Klopp, Norman
A2 - Erdmann, Jeanette
A2 - Assimes, Themistocles L
A2 - Ball, Stephen G
A2 - Balmforth, Anthony J
A2 - Basart, Hanneke
A2 - Baumert, Jens
A2 - Bezzina, Connie R
A2 - Boerwinkle, Eric
A2 - Boehm, Bernhard O
A2 - Brocheton, Jessy
A2 - Bugert, Peter
A2 - Cambien, Francois
A2 - Clarke, Robert
A2 - Codd, Veryan
A2 - Collins, Rory
A2 - Couper, David
A2 - Cupples, L Adrienne
A2 - de Jong, Jonas S
A2 - Diemert, Patrick
A2 - Ejebe, Kenechi
A2 - Elbers, Clara C
A2 - Elliott, Paul
A2 - Fornage, Myriam
A2 - Franzosi, Maria-Grazia
A2 - Frossard, Philippe
A2 - Garner, Stephen
A2 - Goel, Anuj
A2 - Goodall, Alison H
A2 - Hengstenberg, Christian
A2 - Hunt, Sarah E
A2 - Kastelein, John J P
A2 - Klungel, Olaf H
A2 - Klüter, Harald
A2 - Koch, Kerstin
A2 - König, Inke R
A2 - Kooner, Angad S
A2 - Laaksonen, Reijo
A2 - Lathrop, Mark
A2 - Li, Mingyao
A2 - Liu, Kiang
A2 - McPherson, Ruth
A2 - Musameh, Muntaser D
A2 - Musani, Solomon
A2 - Nelson, Christopher P
A2 - O'Donnell, Christopher J
A2 - Ongen, Halit
A2 - Papanicolaou, George
A2 - Peters, Annette
A2 - Peters, Bas J M
A2 - Potter, Simon
A2 - Psaty, Bruce M
A2 - Qu, Liming
A2 - Rader, Daniel J
A2 - Rasheed, Asif
A2 - Rice, Catherine
A2 - Scott, James
A2 - Seedorf, Udo
A2 - Sehmi, Joban S
A2 - Sotoodehnia, Nona
A2 - Stark, Klaus
A2 - Stephens, Jonathan
A2 - van der Schoot, C Ellen
A2 - van der Schouw, Yvonne T
A2 - Thorsteinsdottir, Unnur
A2 - Tomaszewski, Maciej
A2 - van der Harst, Pim
A2 - Vasan, Ramachandran S
A2 - Wilde, Arthur A M
A2 - Willenborg, Christina
A2 - Winkelmann, Bernhard R
A2 - Zaidi, Moazzam
A2 - Zhang, Weihua
A2 - Ziegler, Andreas
A2 - de Bakker, Paul I W
A2 - Koenig, Wolfgang
A2 - Mätz, Winfried
A2 - Trip, Mieke D
A2 - Kathiresan, Sekar
A2 - Schunkert, Heribert
A2 - Hamsten, Anders
A2 - Hall, Alistair S
A2 - Kooner, Jaspal S
A2 - Thompson, Simon G
A2 - Thompson, John R
A2 - Deloukas, Panos
A2 - Ouwehand, Willem H
A2 - Watkins, Hugh
A2 - Danesh, John
A2 - Samani, Nilesh J
A2 - Barnes, Timothy
A2 - Rafelt, Suzanne
A2 - Bruinsma, Nienke
A2 - Dekker, Lukas R
A2 - Henriques, José P
A2 - Koch, Karel T
A2 - de Winter, Robbert J
A2 - Alings, Marco
A2 - Allaart, Cor F
A2 - Gorgels, Anton P
A2 - Verheugt, Freek W
A2 - Mueller, Martina
A2 - Meisinger, Christa
A2 - DerOhannessian, Stephanie
A2 - Mehta, Nehal N
A2 - Ferguson, Jane
A2 - Hakonarson, Hakon
A2 - Matthai, William
A2 - Wilensky, Robert
A2 - Hopewell, J C
A2 - Parish, S
A2 - Linksted, P
A2 - Notman, J
A2 - Gonzalez, H
A2 - Young, A
A2 - Ostley, T
A2 - Munday, A
A2 - Goodwin, N
A2 - Verdon, V
A2 - Shah, S
A2 - Cobb, L
A2 - Edwards, C
A2 - Mathews, C
A2 - Gunter, R
A2 - Benham, J
A2 - Davies, C
A2 - Cobb, M
A2 - Crowther, J
A2 - Richards, A
A2 - Silver, M
A2 - Tochlin, S
A2 - Mozley, S
A2 - Clark, S
A2 - Radley, M
A2 - Kourellias, K
A2 - Silveira, Angela
A2 - Söderholm, Birgitta
A2 - Olsson, Per
A2 - Barlera, Simona
A2 - Tognoni, Gianni
A2 - Rust, Stephan
A2 - Assmann, Gerd
A2 - Heath, Simon
A2 - Zelenika, Diana
A2 - Gut, Ivo
A2 - Green, Fiona
A2 - Peden, John
A2 - Aly, Anette
A2 - Anner, Karolina
A2 - Björklund, Karin
A2 - Blomgren, Gun
A2 - Cederschiöld, Barbro
A2 - Danell-Toverud, Karin
A2 - Eriksson, Per
A2 - Grundstedt, Ulla
A2 - Heinonen, Merja
A2 - Hellénius, Mai-Lis
A2 - van't Hooft, Ferdinand
A2 - Husman, Karin
A2 - Lagercrantz, Jacob
A2 - Larsson, Anita
A2 - Larsson, Malin
A2 - Mossfeldt, Magnus
A2 - Mälarstig, Anders
A2 - Olsson, Gunnar
A2 - Sabater-Lleal, Maria
A2 - Sennblad, Bengt
A2 - Strawbridge, Rona
A2 - Öhrvik, John
A2 - Zaman, Khan Shah
A2 - Mallick, Nadeem Hayat
A2 - Azhar, Muhammad
A2 - Samad, Abdus
A2 - Ishaq, Mohammad
A2 - Shah, Nabi
A2 - Samuel, Maria
A2 - Reilly, Muredach
A2 - Holm, Hilma
A2 - Preuss, Michael
A2 - Stewart, Alexandre F R
A2 - Barbalic, Maja
A2 - Gieger, Christian
A2 - Absher, Devin
A2 - Aherrahrou, Zouhair
A2 - Allayee, Hooman
A2 - Altshuler, David
A2 - Anand, Sonia
A2 - Andersen, Karl
A2 - Anderson, Jeffrey L
A2 - Ardissino, Diego
A2 - Becker, Lewis C
A2 - Becker, Diane M
A2 - Berger, Klaus
A2 - Bis, Joshua C
A2 - Boekholdt, S Matthijs
A2 - Brown, Morris J
A2 - Burnett, Mary Susan
A2 - Buysschaert, Ian
A2 - Carlquist, John F
A2 - Chen, Li
A2 - Davies, Robert W
A2 - Dedoussis, George
A2 - Dehghan, Abbas
A2 - Demissie, Serkalem
A2 - Devaney, Joseph
A2 - Do, Ron
A2 - Doering, Angela
A2 - El Mokhtari, Nour Eddine
A2 - Ellis, Stephen G
A2 - Elosua, Roberto
A2 - Engert, James C
A2 - Epstein, Stephen
A2 - de Faire, Ulf
A2 - Fischer, Marcus
A2 - Folsom, Aaron R
A2 - Freyer, Jennifer
A2 - Gigante, Bruna
A2 - Girelli, Domenico
A2 - Gretarsdottir, Solveig
A2 - Gudnason, Vilmundur
A2 - Gulcher, Jeffrey R
A2 - Tennstedt, Stephanie
A2 - Halperin, Eran
A2 - Hammond, Naomi
A2 - Hazen, Stanley L
A2 - Hofman, Albert
A2 - Horne, Benjamin D
A2 - Illig, Thomas
A2 - Iribarren, Carlos
A2 - Jones, Gregory T
A2 - Jukema, J Wouter
A2 - Kaiser, Michael A
A2 - Kaplan, Lee M
A2 - Khaw, Kay-Tee
A2 - Knowles, Joshua W
A2 - Kolovou, Genovefa
A2 - Kong, Augustine
A2 - Lambrechts, Diether
A2 - Leander, Karin
A2 - Lieb, Wolfgang
A2 - Lettre, Guillaume
A2 - Loley, Christina
A2 - Lotery, Andrew J
A2 - Mannucci, Pier M
A2 - Maouche, Seraya
A2 - Martinelli, Nicola
A2 - McKeown, Pascale P
A2 - Meitinger, Thomas
A2 - Melander, Olle
A2 - Merlini, Pier Angelica
A2 - Mooser, Vincent
A2 - Morgan, Thomas
A2 - Mühleisen, Thomas W
A2 - Muhlestein, Joseph B
A2 - Musunuru, Kiran
A2 - Nahrstaedt, Janja
A2 - Nöthen, Markus M
A2 - Olivieri, Oliviero
A2 - Peyvandi, Flora
A2 - Patel, Riyaz S
A2 - Patterson, Chris C
A2 - Quyyumi, Arshed A
A2 - Rallidis, Loukianos S
A2 - Rosendaal, Frits R
A2 - Rubin, Diana
A2 - Salomaa, Veikko
A2 - Sampietro, M Lourdes
A2 - Sandhu, Manj S
A2 - Schadt, Eric
A2 - Schäfer, Arne
A2 - Schillert, Arne
A2 - Schreiber, Stefan
A2 - Schrezenmeir, Jürgen
A2 - Schwartz, Stephen M
A2 - Siscovick, David S
A2 - Sivananthan, Mohan
A2 - Smith, Albert V
A2 - Smith, Tamara B
A2 - Snoep, Jaapjan D
A2 - Spertus, John A
A2 - Stefansson, Kari
A2 - Stirrups, Kathy
A2 - Stoll, Monika
A2 - Tang, W H Wilson
A2 - Thorgeirsson, Gudmundur
A2 - Thorleifsson, Gudmar
A2 - Uitterlinden, Andre G
A2 - van Rij, Andre M
A2 - Voight, Benjamin F
A2 - Wareham, Nick J
A2 - AWells, George
A2 - Wichmann, H-Erich
A2 - Witteman, Jaqueline C M
A2 - Wright, Benjamin J
A2 - Ye, Shu
A2 - Quertermous, Thomas
A2 - März, Winfried
A2 - Blankenberg, Stefan
A2 - Roberts, Robert
A2 - Onland-Moret, N Charlotte
A2 - van Setten, Jessica
A2 - Verschuren, W M Monique
A2 - Boer, Jolanda M A
A2 - Wijmenga, Cisca
A2 - Hofker, Marten H
A2 - Maitland-van der Zee, Anke-Hilse
A2 - de Boer, Anthonius
A2 - Grobbee, Diederick E
A2 - Attwood, Tony
A2 - Belz, Stephanie
A2 - Braund, Peter
A2 - Cambien, François
A2 - Cooper, Jason
A2 - Crisp-Hihn, Abi
A2 - Foad, Nicola
A2 - Gracey, Jay
A2 - Gray, Emma
A2 - Gwilliams, Rhian
A2 - Heimerl, Susanne
A2 - Jolley, Jennifer
A2 - Krishnan, Unni
A2 - Lloyd-Jones, Heather
A2 - Lugauer, Ingrid
A2 - Lundmark, Per
A2 - Moore, Jasbir S
A2 - Muir, David
A2 - Murray, Elizabeth
A2 - Nelson, Chris P
A2 - Neudert, Jessica
A2 - Niblett, David
A2 - O'Leary, Karen
A2 - Pollard, Helen
A2 - Rankin, Angela
A2 - Rice, Catherine M
A2 - Sager, Hendrik
A2 - Sambrook, Jennifer
A2 - Schmitz, Gerd
A2 - Scholz, Michael
A2 - Schroeder, Laura
A2 - Syvannen, Ann-Christine
A2 - Wallace, Chris
N1 - 090532, Wellcome Trust, United KingdomG0401527, Medical Research Council, United KingdomG0601966, Medical Research Council, United KingdomG0700931, Medical Research Council, United KingdomG0701863, Medical Research Council, United KingdomG0801056, Medical Research Council, United KingdomG1000143, Medical Research Council, United KingdomMC_U105260792, Medical Research Council, United KingdomMC_U106179471, Medical Research Council, United KingdomMC_U137686857, Medical Research Council, United KingdomR01 HL087647, NHLBI NIH HHS, United StatesRG/08/014/24067, British Heart Foundation, United KingdomRG/09/12/28096, British Heart Foundation, United Kingdom, Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom
PY - 2011/9
Y1 - 2011/9
N2 - Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p
AB - Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p
U2 - 10.1371/journal.pgen.1002260
DO - 10.1371/journal.pgen.1002260
M3 - Article
C2 - 21966275
SN - 1553-7390
VL - 7
JO - PL o S Genetics
JF - PL o S Genetics
IS - 9
ER -