Least-squares (LS) deconvolution of a series of overlapping cortical auditory evoked potentials

Fabrice Bardy, Bram Van Dun, Harvey Dillon, Robert Cowan

Research output: Contribution to journalArticlepeer-review


Objective. To evaluate the viability of disentangling a series of overlapping 'cortical auditory evoked potentials' (CAEPs) elicited by different stimuli using least-squares (LS) deconvolution, and to assess the adaptation of CAEPs for different stimulus onset-asynchronies (SOAs). Approach. Optimal aperiodic stimulus sequences were designed by controlling the condition number of matrices associated with the LS deconvolution technique. First, theoretical considerations of LS deconvolution were assessed in simulations in which multiple artificial overlapping responses were recovered. Second, biological CAEPs were recorded in response to continuously repeated stimulus trains containing six different tone-bursts with frequencies 8, 4, 2, 1, 0.5, 0.25 kHz separated by SOAs jittered around 150 (120-185), 250 (220-285) and 650 (620-685) ms. The control condition had a fixed SOA of 1175 ms. In a second condition, using the same SOAs, trains of six stimuli were separated by a silence gap of 1600 ms. Twenty-four adults with normal hearing (
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalJournal of Neural Engineering
Issue number4
Publication statusPublished - 25 Jun 2014


  • Cortical auditory evoked potentials
  • Least-squares deconvolution
  • Low-jittering
  • Multiple overlapping responses
  • SNR


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