Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

T. Z. Aziz; D. Peggs; M. A. Sambrook; A. R. Crossman

doi:10.1002/mds.870060404

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

T. Z. Aziz, D. Peggs, M. A. Sambrook, A. R. Crossman

Research output: Contribution to journal › Article › peer-review

Abstract

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

Original language	English
Pages (from-to)	288-292
Number of pages	4
Journal	Movement Disorders
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/mds.870060404
Publication status	Published - 1991

Keywords

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain Mapping
drug effects: Dominance, Cerebral
Macaca fascicularis
Neurologic Examination
chemically induced: Parkinson Disease, Secondary
Radiosurgery
physiopathology: Thalamic Nuclei

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10.1002/mds.870060404

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title = "Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate",

abstract = "Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.",

keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Brain Mapping, drug effects: Dominance, Cerebral, Macaca fascicularis, Neurologic Examination, chemically induced: Parkinson Disease, Secondary, Radiosurgery, physiopathology: Thalamic Nuclei",

author = "Aziz, {T. Z.} and D. Peggs and Sambrook, {M. A.} and Crossman, {A. R.}",

year = "1991",

doi = "10.1002/mds.870060404",

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pages = "288--292",

journal = "Movement Disorders",

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T1 - Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

AU - Aziz, T. Z.

AU - Peggs, D.

AU - Sambrook, M. A.

AU - Crossman, A. R.

PY - 1991

Y1 - 1991

N2 - Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

AB - Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

KW - Animals

KW - Brain Mapping

KW - drug effects: Dominance, Cerebral

KW - Macaca fascicularis

KW - Neurologic Examination

KW - chemically induced: Parkinson Disease, Secondary

KW - Radiosurgery

KW - physiopathology: Thalamic Nuclei

U2 - 10.1002/mds.870060404

DO - 10.1002/mds.870060404

M3 - Article

SN - 0885-3185

VL - 6

SP - 288

EP - 292

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

Abstract

Keywords

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