Leukemogenic Activity of Cohesin Rings True.

Mark S Williams; Tim C P Somervaille

doi:10.1016/j.stem.2015.11.008

Leukemogenic Activity of Cohesin Rings True.

Mark S Williams, Tim C P Somervaille

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.

Original language	English
Journal	Cell Stem Cell
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2015.11.008
Publication status	Published - 3 Dec 2015

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Manchester Cancer Research Centre

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10.1016/j.stem.2015.11.008

Cite this

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title = "Leukemogenic Activity of Cohesin Rings True.",

abstract = "Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.",

author = "Williams, {Mark S} and Somervaille, {Tim C P}",

year = "2015",

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AU - Somervaille, Tim C P

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AB - Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.

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JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 6

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Leukemogenic Activity of Cohesin Rings True.

Abstract

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UN SDGs

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