Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis

Robert M. Plenge; Soumya Raychaudhuri

doi:10.1016/j.rdc.2010.03.002

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis

Robert M. Plenge, Soumya Raychaudhuri

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this article is to place these genetic discoveries in the context of current and future therapeutic strategies for patients with RA. More specifically, this article focuses on (1) a brief overview of genetic studies, (2) human genetics as an approach to identify the Achilles heel of disease pathways, (3) humans as the model organism for functional studies of human mutations, (4) pharmacogenetic studies to gain insight into the mechanism of action of drugs, and (5) next-generation patient registries to enable large-scale genotype-phenotype studies. © 2010 Elsevier Inc.

Original language	English
Pages (from-to)	259-270
Number of pages	11
Journal	Rheumatic Disease Clinics of North America
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.rdc.2010.03.002
Publication status	Published - May 2010

Keywords

Allele
Human genetics
Locus
Mutation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rdc.2010.03.002

Cite this

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abstract = "The purpose of this article is to place these genetic discoveries in the context of current and future therapeutic strategies for patients with RA. More specifically, this article focuses on (1) a brief overview of genetic studies, (2) human genetics as an approach to identify the Achilles heel of disease pathways, (3) humans as the model organism for functional studies of human mutations, (4) pharmacogenetic studies to gain insight into the mechanism of action of drugs, and (5) next-generation patient registries to enable large-scale genotype-phenotype studies. {\textcopyright} 2010 Elsevier Inc.",

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AU - Raychaudhuri, Soumya

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AB - The purpose of this article is to place these genetic discoveries in the context of current and future therapeutic strategies for patients with RA. More specifically, this article focuses on (1) a brief overview of genetic studies, (2) human genetics as an approach to identify the Achilles heel of disease pathways, (3) humans as the model organism for functional studies of human mutations, (4) pharmacogenetic studies to gain insight into the mechanism of action of drugs, and (5) next-generation patient registries to enable large-scale genotype-phenotype studies. © 2010 Elsevier Inc.

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KW - Locus

KW - Mutation

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JF - Rheumatic Disease Clinics of North America

SN - 1558-3163

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ER -

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis

Abstract

Keywords

UN SDGs

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