Life with 6000 genes

A. Goffeau; G. Barrell; H. Bussey; R. W. Davis; B. Dujon; H. Feldmann; F. Galibert; J. D. Hoheisel; C. Jacq; M. Johnston; E. J. Louis; H. W. Mewes; Y. Murakami; P. Philippsen; H. Tettelin; S. G. Oliver

doi:10.1126/science.274.5287.546

Life with 6000 genes

A. Goffeau, G. Barrell, H. Bussey, R. W. Davis, B. Dujon, H. Feldmann, F. Galibert, J. D. Hoheisel, C. Jacq, M. Johnston, E. J. Louis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, S. G. Oliver

Research output: Contribution to journal › Article › peer-review

Abstract

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

Original language	English
Pages (from-to)	546-567
Number of pages	21
Journal	Science
Volume	274
Issue number	5287
DOIs	https://doi.org/10.1126/science.274.5287.546
Publication status	Published - 1996

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1126/science.274.5287.546

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title = "Life with 6000 genes",

abstract = "The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.",

author = "A. Goffeau and G. Barrell and H. Bussey and Davis, {R. W.} and B. Dujon and H. Feldmann and F. Galibert and Hoheisel, {J. D.} and C. Jacq and M. Johnston and Louis, {E. J.} and Mewes, {H. W.} and Y. Murakami and P. Philippsen and H. Tettelin and Oliver, {S. G.}",

year = "1996",

doi = "10.1126/science.274.5287.546",

language = "English",

volume = "274",

pages = "546--567",

journal = "Science",

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TY - JOUR

T1 - Life with 6000 genes

AU - Goffeau, A.

AU - Barrell, G.

AU - Bussey, H.

AU - Davis, R. W.

AU - Dujon, B.

AU - Feldmann, H.

AU - Galibert, F.

AU - Hoheisel, J. D.

AU - Jacq, C.

AU - Johnston, M.

AU - Louis, E. J.

AU - Mewes, H. W.

AU - Murakami, Y.

AU - Philippsen, P.

AU - Tettelin, H.

AU - Oliver, S. G.

PY - 1996

Y1 - 1996

N2 - The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

AB - The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

U2 - 10.1126/science.274.5287.546

DO - 10.1126/science.274.5287.546

M3 - Article

C2 - 8849441

SN - 0036-8075

VL - 274

SP - 546

EP - 567

JO - Science

JF - Science

IS - 5287

ER -

Life with 6000 genes

Abstract

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