Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index

Andrew Renehan; D. J. Harriss; G. Atkinson; K. George; N. Tim Cable; T. Reilly; N. Haboubi; M. Zwahlen; M. Egger; A. G. Renehan

doi:10.1111/j.1463-1318.2009.01766.x

Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index

Andrew Renehan, D. J. Harriss, G. Atkinson, K. George, N. Tim Cable, T. Reilly, N. Haboubi, M. Zwahlen, M. Egger, A. G. Renehan

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. Method: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m2 increase in BMI. Results: We analysed 29 datasets from 28 articles, including 67361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P

Original language	English
Pages (from-to)	547-563
Number of pages	16
Journal	Colorectal Disease
Volume	11
Issue number	6
DOIs	https://doi.org/10.1111/j.1463-1318.2009.01766.x
Publication status	Published - Jul 2009

Keywords

Body mass index
Colorectal cancer risk
Obesity
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1463-1318.2009.01766.x

Cite this

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title = "Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index",

abstract = "Objective: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. Method: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m2 increase in BMI. Results: We analysed 29 datasets from 28 articles, including 67361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P",

keywords = "Body mass index, Colorectal cancer risk, Obesity, Systematic review",

author = "Andrew Renehan and Harriss, {D. J.} and G. Atkinson and K. George and {Tim Cable}, N. and T. Reilly and N. Haboubi and M. Zwahlen and M. Egger and Renehan, {A. G.}",

year = "2009",

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doi = "10.1111/j.1463-1318.2009.01766.x",

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T1 - Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index

AU - Renehan, Andrew

AU - Harriss, D. J.

AU - Atkinson, G.

AU - George, K.

AU - Tim Cable, N.

AU - Reilly, T.

AU - Haboubi, N.

AU - Zwahlen, M.

AU - Egger, M.

AU - Renehan, A. G.

PY - 2009/7

Y1 - 2009/7

N2 - Objective: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. Method: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m2 increase in BMI. Results: We analysed 29 datasets from 28 articles, including 67361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P

AB - Objective: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. Method: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m2 increase in BMI. Results: We analysed 29 datasets from 28 articles, including 67361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P

KW - Body mass index

KW - Colorectal cancer risk

KW - Obesity

KW - Systematic review

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DO - 10.1111/j.1463-1318.2009.01766.x

M3 - Article

SN - 1462-8910

VL - 11

SP - 547

EP - 563

JO - Colorectal Disease

JF - Colorectal Disease

IS - 6

ER -

Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index

Abstract

Keywords

UN SDGs

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