Ligand-mediated enantioselective synthesis of acyclic pyrrole carbinols

Darren J. Dixon; Mark S. Scott; Chris A. Luckhurst

doi:10.1055/s-2005-872698

Ligand-mediated enantioselective synthesis of acyclic pyrrole carbinols

Darren J. Dixon, Mark S. Scott, Chris A. Luckhurst

Research output: Contribution to journal › Article › peer-review

Abstract

The enantioselective synthesis of acyclic pyrrole carbinols via ligand-mediated addition of lithium pyrrolate to aldehydes, and subsequent exploitation of the resulting stereocentre as a stereodirecting group in syn- or anti-selective 1,3-reductions of ketone functionality in the parent aldehyde is described. © Georg Thieme Verlag Stuttgart.

Original language	English
Article number	D19005ST
Pages (from-to)	2420-2424
Number of pages	4
Journal	SYNLETT
Issue number	16
DOIs	https://doi.org/10.1055/s-2005-872698
Publication status	Published - 4 Oct 2005

Keywords

Aldehydes
Asymmetric synthesis
Ligands
Lithium
Pyrrole carbinol

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10.1055/s-2005-872698

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title = "Ligand-mediated enantioselective synthesis of acyclic pyrrole carbinols",

abstract = "The enantioselective synthesis of acyclic pyrrole carbinols via ligand-mediated addition of lithium pyrrolate to aldehydes, and subsequent exploitation of the resulting stereocentre as a stereodirecting group in syn- or anti-selective 1,3-reductions of ketone functionality in the parent aldehyde is described. {\textcopyright} Georg Thieme Verlag Stuttgart.",

keywords = "Aldehydes, Asymmetric synthesis, Ligands, Lithium, Pyrrole carbinol",

author = "Dixon, {Darren J.} and Scott, {Mark S.} and Luckhurst, {Chris A.}",

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AU - Dixon, Darren J.

AU - Scott, Mark S.

AU - Luckhurst, Chris A.

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Y1 - 2005/10/4

N2 - The enantioselective synthesis of acyclic pyrrole carbinols via ligand-mediated addition of lithium pyrrolate to aldehydes, and subsequent exploitation of the resulting stereocentre as a stereodirecting group in syn- or anti-selective 1,3-reductions of ketone functionality in the parent aldehyde is described. © Georg Thieme Verlag Stuttgart.

AB - The enantioselective synthesis of acyclic pyrrole carbinols via ligand-mediated addition of lithium pyrrolate to aldehydes, and subsequent exploitation of the resulting stereocentre as a stereodirecting group in syn- or anti-selective 1,3-reductions of ketone functionality in the parent aldehyde is described. © Georg Thieme Verlag Stuttgart.

KW - Aldehydes

KW - Asymmetric synthesis

KW - Ligands

KW - Lithium

KW - Pyrrole carbinol

U2 - 10.1055/s-2005-872698

DO - 10.1055/s-2005-872698

M3 - Article

SN - 1437-2096

SP - 2420

EP - 2424

JO - SYNLETT

JF - SYNLETT

IS - 16

M1 - D19005ST

ER -

Ligand-mediated enantioselective synthesis of acyclic pyrrole carbinols

Abstract

Keywords

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