Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: Its significance in cartilage repair and replacement

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cartilage repair is a major goal of modern tissue engineering. To produce novel engineered implants requires a knowledge of the basic biology of the tissues that are to be replaced or reproduced. Hyaline articular cartilage and meniscal fibrocartilage are two tissues that have excited attention because of the frequency with which they are damaged. A basic strategy is to re-engineer these tissues ex vivo by stimulating stem cells to differentiate into the cells of the mature tissue capable of producing an intact functional matrix. In this brief review, the sources of cells for tissue engineering cartilage and the culture conditions that have promoted differentiation are discussed within the context of natural cartilage repair. In particular, the role of cell density, cytokines, load, matrices and oxygen tension are discussed. © 2005 Elsevier Ireland Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)32-36
    Number of pages4
    JournalEuropean Journal of Radiology
    Volume57
    Issue number1
    DOIs
    Publication statusPublished - Jan 2006

    Keywords

    • Cartilage
    • Fibrocartilage
    • Injury
    • Repair

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