Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.

Robert Ford; John Schuetz; Dominic Marshall-Sabey

doi:10.1016/j.tibs.2019.11.004

Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.

Robert Ford, John Schuetz, Dominic Marshall-Sabey

Division of Molecular & Cellular Function (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional domains to be linked. The recent availability of structures of ABC transporters containing linker regions has allowed us to identify the start and end points of the connectors as well as hinting at their localisation. We address questions such as: Where did the linker regions come from? Why do some ABC transporters have connectors and others not? What are the rules and roles of the linker regions? What are the consequences of mutations in these connector regions for disease in humans?

Original language	English
Article number	doi.org/10.1016/j.tibs.2019.11.004
Pages (from-to)	137-148
Number of pages	11
Journal	Trends in biochemical sciences
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/j.tibs.2019.11.004
Publication status	Published - 12 Dec 2019

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10.1016/j.tibs.2019.11.004

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title = "Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.",

abstract = "ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional domains to be linked. The recent availability of structures of ABC transporters containing linker regions has allowed us to identify the start and end points of the connectors as well as hinting at their localisation. We address questions such as: Where did the linker regions come from? Why do some ABC transporters have connectors and others not? What are the rules and roles of the linker regions? What are the consequences of mutations in these connector regions for disease in humans?",

author = "Robert Ford and John Schuetz and Dominic Marshall-Sabey",

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T1 - Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.

AU - Ford, Robert

AU - Schuetz, John

AU - Marshall-Sabey, Dominic

PY - 2019/12/12

Y1 - 2019/12/12

N2 - ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional domains to be linked. The recent availability of structures of ABC transporters containing linker regions has allowed us to identify the start and end points of the connectors as well as hinting at their localisation. We address questions such as: Where did the linker regions come from? Why do some ABC transporters have connectors and others not? What are the rules and roles of the linker regions? What are the consequences of mutations in these connector regions for disease in humans?

AB - ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional domains to be linked. The recent availability of structures of ABC transporters containing linker regions has allowed us to identify the start and end points of the connectors as well as hinting at their localisation. We address questions such as: Where did the linker regions come from? Why do some ABC transporters have connectors and others not? What are the rules and roles of the linker regions? What are the consequences of mutations in these connector regions for disease in humans?

U2 - 10.1016/j.tibs.2019.11.004

DO - 10.1016/j.tibs.2019.11.004

M3 - Review article

SN - 0968-0004

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EP - 148

JO - Trends in biochemical sciences

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IS - 2

M1 - doi.org/10.1016/j.tibs.2019.11.004

ER -

Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.

Abstract

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