Lipid Kinases: Charging PtdIns(4,5)P2 Synthesis

Nullin Divecha

Research output: Contribution to journalArticlepeer-review


Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)R154-R157
JournalCurrent Biology
Issue number4
Publication statusPublished - 23 Feb 2010

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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