Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

Karen A. Massey; Anna Nicolaou

doi:10.1042/BST0391240

Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

Research output: Contribution to journal › Article › peer-review

Abstract

Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, aswell as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. ©The Authors Journal compilation ©2011 Biochemical Society.

Original language	English
Pages (from-to)	1240-1246
Number of pages	6
Journal	Biochemical Society Transactions
Volume	39
Issue number	5
DOIs	https://doi.org/10.1042/BST0391240
Publication status	Published - Oct 2011

Keywords

Cyclo-oxygenase (COX)
Cytochrome P450 (CYP450)
Eicosanoid
Lipoxygenase (LOX)
Mass spectrometry
Polyunsaturated fatty acid (PUFA)

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10.1042/BST0391240

http://www.biochemsoctrans.org/bst/039/1240/0391240.pdf

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title = "Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites",

abstract = "Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, aswell as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. {\textcopyright}The Authors Journal compilation {\textcopyright}2011 Biochemical Society.",

keywords = "Cyclo-oxygenase (COX), Cytochrome P450 (CYP450), Eicosanoid, Lipoxygenase (LOX), Mass spectrometry, Polyunsaturated fatty acid (PUFA)",

author = "Massey, {Karen A.} and Anna Nicolaou",

year = "2011",

month = oct,

doi = "10.1042/BST0391240",

language = "English",

volume = "39",

pages = "1240--1246",

journal = "Biochemical Society Transactions",

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T1 - Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

AU - Massey, Karen A.

AU - Nicolaou, Anna

PY - 2011/10

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N2 - Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, aswell as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. ©The Authors Journal compilation ©2011 Biochemical Society.

AB - Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, aswell as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. ©The Authors Journal compilation ©2011 Biochemical Society.

KW - Cyclo-oxygenase (COX)

KW - Cytochrome P450 (CYP450)

KW - Eicosanoid

KW - Lipoxygenase (LOX)

KW - Mass spectrometry

KW - Polyunsaturated fatty acid (PUFA)

U2 - 10.1042/BST0391240

DO - 10.1042/BST0391240

M3 - Article

C2 - 21936796

SN - 1470-8752

VL - 39

SP - 1240

EP - 1246

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 5

ER -

Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

Abstract

Keywords

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