Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats

F. Carey, R. Forder, M. D. Edge, A. R. Greene, M. A. Horan, P. J L M Strijbos, N. J. Rothwell

Research output: Contribution to journalArticlepeer-review

Abstract

Lipocortins form a group of proteins that have been proposed as mediators of the anti-inflammatory actions of glucocorticoids. Intracerebroventricular injection of a recombinant fragment of lipocortin 1 (NH2-terminal 1-188) caused dose-dependent (0.4-1.2 μg) reductions in the acute increases in colonic temperature and oxygen consumption, which occurred in response to central injections of recombinant interleukin 1β and γ-interferon in conscious rats. In contrast the lipocortin fragment did not affect the response to prostaglandin E2, and its activity was prevented by heat treatment or by pretreatment of animals with polyclonal antiserum raised to the fragment. Central injection of antiserum significantly enhanced the thermogenic responses to interleukin 1β in rats treated with dexamethasone without affecting the responses in normal animals. These results support a physiological role for lipocortin in the central effects of glucocorticoids.
Original languageEnglish
Pages (from-to)R266-R269
JournalAJP: Regulatory, Integrative and Comparative Physiology
Volume259
Issue number2
Publication statusPublished - 1990

Keywords

  • fever
  • glucocorticoids
  • thermogenesis

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