Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes

S. Mascia; M. J. Patel; S. L. Rough; P. J. Martin; D. I. Wilson

doi:10.1016/j.ejps.2006.04.011

Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes

S. Mascia, M. J. Patel, S. L. Rough, P. J. Martin, D. I. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Extensive movement of the liquid phase relative to the solids in solid-liquid pastes during extrusion forming is an undesirable process phenomenon. The impact of formulation and flow pattern on liquid phase migration (LPM) during extrusion of model pharmaceutical pastes (40-50 wt% microcrystalline cellulose/water) has been investigated by ram extrusion through square-entry and 45° conical-entry dies, and by lubricated squeeze flow (extensional flow). Threshold velocities for LPM were observed in both configurations. Squeeze flow testing showed that dilation during extension can cause LPM, while ram extrusion featured both dilation effects and drainage due to compaction. The threshold velocities observed in the two configurations agreed when presented as characteristic shear rates. The threshold velocity increased with paste solids content. © 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	22-34
Number of pages	12
Journal	European Journal of Pharmaceutical Sciences
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.ejps.2006.04.011
Publication status	Published - Sept 2006

Keywords

Conical-entry die
Dewatering
Dilation
Extrusion
Microcrystalline cellulose
Square-entry die
Squeeze flow

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10.1016/j.ejps.2006.04.011

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title = "Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes",

abstract = "Extensive movement of the liquid phase relative to the solids in solid-liquid pastes during extrusion forming is an undesirable process phenomenon. The impact of formulation and flow pattern on liquid phase migration (LPM) during extrusion of model pharmaceutical pastes (40-50 wt% microcrystalline cellulose/water) has been investigated by ram extrusion through square-entry and 45° conical-entry dies, and by lubricated squeeze flow (extensional flow). Threshold velocities for LPM were observed in both configurations. Squeeze flow testing showed that dilation during extension can cause LPM, while ram extrusion featured both dilation effects and drainage due to compaction. The threshold velocities observed in the two configurations agreed when presented as characteristic shear rates. The threshold velocity increased with paste solids content. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",

keywords = "Conical-entry die, Dewatering, Dilation, Extrusion, Microcrystalline cellulose, Square-entry die, Squeeze flow",

author = "S. Mascia and Patel, {M. J.} and Rough, {S. L.} and Martin, {P. J.} and Wilson, {D. I.}",

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doi = "10.1016/j.ejps.2006.04.011",

language = "English",

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TY - JOUR

T1 - Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes

AU - Mascia, S.

AU - Patel, M. J.

AU - Rough, S. L.

AU - Martin, P. J.

AU - Wilson, D. I.

N1 - Times Cited: 12

PY - 2006/9

Y1 - 2006/9

N2 - Extensive movement of the liquid phase relative to the solids in solid-liquid pastes during extrusion forming is an undesirable process phenomenon. The impact of formulation and flow pattern on liquid phase migration (LPM) during extrusion of model pharmaceutical pastes (40-50 wt% microcrystalline cellulose/water) has been investigated by ram extrusion through square-entry and 45° conical-entry dies, and by lubricated squeeze flow (extensional flow). Threshold velocities for LPM were observed in both configurations. Squeeze flow testing showed that dilation during extension can cause LPM, while ram extrusion featured both dilation effects and drainage due to compaction. The threshold velocities observed in the two configurations agreed when presented as characteristic shear rates. The threshold velocity increased with paste solids content. © 2006 Elsevier B.V. All rights reserved.

AB - Extensive movement of the liquid phase relative to the solids in solid-liquid pastes during extrusion forming is an undesirable process phenomenon. The impact of formulation and flow pattern on liquid phase migration (LPM) during extrusion of model pharmaceutical pastes (40-50 wt% microcrystalline cellulose/water) has been investigated by ram extrusion through square-entry and 45° conical-entry dies, and by lubricated squeeze flow (extensional flow). Threshold velocities for LPM were observed in both configurations. Squeeze flow testing showed that dilation during extension can cause LPM, while ram extrusion featured both dilation effects and drainage due to compaction. The threshold velocities observed in the two configurations agreed when presented as characteristic shear rates. The threshold velocity increased with paste solids content. © 2006 Elsevier B.V. All rights reserved.

KW - Conical-entry die

KW - Dewatering

KW - Dilation

KW - Extrusion

KW - Microcrystalline cellulose

KW - Square-entry die

KW - Squeeze flow

U2 - 10.1016/j.ejps.2006.04.011

DO - 10.1016/j.ejps.2006.04.011

M3 - Article

SN - 0928-0987

VL - 29

SP - 22

EP - 34

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 1

ER -

Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes

Abstract

Keywords

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