Local anatomic changes in parotid and submandibular glands during radiotherapy for oropharynx cancer and correlation with dose, studied in detail with nonrigid registration

Eliana M Vásquez Osorio, Mischa S Hoogeman, Abrahim Al-Mamgani, David N Teguh, Peter C Levendag, Ben J M Heijmen

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To quantify the anatomic changes caused by external beam radiotherapy in head-and-neck cancer patients in full three dimensions and to relate the local anatomic changes to the planned mean dose.

METHODS AND MATERIALS: A nonrigid registration method was adapted for RT image registration. The method was applied in 10 head-and-neck cancer patients, who each underwent a planning and a repeat computed tomography scan. Contoured structures (parotid, submandibular glands, and tumor) were registered in a nonrigid manner. The accuracy of the transformation was determined. The transformation results were used to summarize the anatomic changes on a local scale for the irradiated and spared glands. The volume reduction of the glands was related to the planned mean dose.

RESULTS: Transformation was accurate with a mean error of 0.6 +/- 0.5 mm. The volume of all glands and the primary tumor decreased. The lateral regions of the irradiated parotid glands moved inward (average, 3 mm), and the medial regions tended to remain in the same position. The irradiated submandibular glands shrank and moved upward. The spared glands showed only a small deformation ( approximately 1 mm in most regions). Overall, the primary tumors shrank. The volume loss of the parotid glands correlated significantly with the planned mean dose (p <0.001).

CONCLUSION: General shrinkage and deformation of irradiated glands was seen. The spared glands showed few changes. These changes were assessed by a nonrigid registration method, which effectively described the local changes occurring in the head-and-neck region after external beam radiotherapy.

Original languageEnglish
Pages (from-to)875-882
Number of pages8
JournalInternational journal of radiation oncology, biology, physics
Volume70
Issue number3
DOIs
Publication statusPublished - 1 Mar 2008

Keywords

  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organ Size
  • Oropharyngeal Neoplasms
  • Parotid Gland
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Submandibular Gland
  • Tomography, X-Ray Computed
  • Journal Article

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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