Local drug delivery from coronary stents in the porcine coronary artery

J. Armstrong, J. Gunn, C. M. Holt, N. Malik, L. Rowan, P. Stratford, D. C. Cumberland

    Research output: Contribution to journalArticlepeer-review


    Background. Local drug delivery from a polymer coated stent is a novel concept to prevent restenosis. Angiopeptin has been shown to reduce intimal hyperplasia. We aimed to characterise the release kinetics and distribution of angiopeptin loaded onto phosphorylcholine- (PC-) coated BiodivYsio (Biocompatibles) stents in vivo. Methods. PC-coated stents were loaded with a mean 9.3μg 125I-labelled angiopeptin and deployed in porcine anterior descending arteries. The RCA and Cx arteries were controls. The pigs (n=6) were killed at 1 h, 24 h and 7 days. Surface measurements and blood, urine and tissue samples were analysed. Results. A mean 99% of the immediate post-deployment Geiger surface count persisted at 30 min and 43% at 7 days. At 24h, the amount of drug retrieved was 0.37μg in the stent coating, 419.3pg/mg arterial wall round stent, 7.5pg/mg adjacent unstented LAD, 4.2pg/mg myocardium, 0.6pg/mg RCA, 0.3pg/mg liver, 1.9pg/mg kidney and 75pg/mg blood. Conclusion. Efficient, sustained and truly local delivery of angiopeptin into coronary artery wall can be achieved by loading onto a PC-coated stent. Later timepoints and efficacy are now being studied.
    Original languageEnglish
    Pages (from-to)P23
    Issue number1
    Publication statusPublished - May 1999


    Dive into the research topics of 'Local drug delivery from coronary stents in the porcine coronary artery'. Together they form a unique fingerprint.

    Cite this