TY - JOUR
T1 - Local drug delivery from coronary stents in the porcine coronary artery
AU - Armstrong, J.
AU - Gunn, J.
AU - Holt, C. M.
AU - Malik, N.
AU - Rowan, L.
AU - Stratford, P.
AU - Cumberland, D. C.
PY - 1999/5
Y1 - 1999/5
N2 - Background. Local drug delivery from a polymer coated stent is a novel concept to prevent restenosis. Angiopeptin has been shown to reduce intimal hyperplasia. We aimed to characterise the release kinetics and distribution of angiopeptin loaded onto phosphorylcholine- (PC-) coated BiodivYsio (Biocompatibles) stents in vivo. Methods. PC-coated stents were loaded with a mean 9.3μg 125I-labelled angiopeptin and deployed in porcine anterior descending arteries. The RCA and Cx arteries were controls. The pigs (n=6) were killed at 1 h, 24 h and 7 days. Surface measurements and blood, urine and tissue samples were analysed. Results. A mean 99% of the immediate post-deployment Geiger surface count persisted at 30 min and 43% at 7 days. At 24h, the amount of drug retrieved was 0.37μg in the stent coating, 419.3pg/mg arterial wall round stent, 7.5pg/mg adjacent unstented LAD, 4.2pg/mg myocardium, 0.6pg/mg RCA, 0.3pg/mg liver, 1.9pg/mg kidney and 75pg/mg blood. Conclusion. Efficient, sustained and truly local delivery of angiopeptin into coronary artery wall can be achieved by loading onto a PC-coated stent. Later timepoints and efficacy are now being studied.
AB - Background. Local drug delivery from a polymer coated stent is a novel concept to prevent restenosis. Angiopeptin has been shown to reduce intimal hyperplasia. We aimed to characterise the release kinetics and distribution of angiopeptin loaded onto phosphorylcholine- (PC-) coated BiodivYsio (Biocompatibles) stents in vivo. Methods. PC-coated stents were loaded with a mean 9.3μg 125I-labelled angiopeptin and deployed in porcine anterior descending arteries. The RCA and Cx arteries were controls. The pigs (n=6) were killed at 1 h, 24 h and 7 days. Surface measurements and blood, urine and tissue samples were analysed. Results. A mean 99% of the immediate post-deployment Geiger surface count persisted at 30 min and 43% at 7 days. At 24h, the amount of drug retrieved was 0.37μg in the stent coating, 419.3pg/mg arterial wall round stent, 7.5pg/mg adjacent unstented LAD, 4.2pg/mg myocardium, 0.6pg/mg RCA, 0.3pg/mg liver, 1.9pg/mg kidney and 75pg/mg blood. Conclusion. Efficient, sustained and truly local delivery of angiopeptin into coronary artery wall can be achieved by loading onto a PC-coated stent. Later timepoints and efficacy are now being studied.
M3 - Article
VL - 81
SP - P23
JO - Heart
JF - Heart
SN - 1355-6037
IS - 1
ER -