Local potassium signaling couples neuronal activity to vasodilation in the brain

Jessica A. Filosa; Adrian D. Bonev; Stephen V. Straub; Andrea L. Meredith; M. Keith Wilkerson; Richard W. Aldrich; Mark T. Nelson

doi:10.1038/nn1779

Local potassium signaling couples neuronal activity to vasodilation in the brain

Jessica A. Filosa, Adrian D. Bonev, Stephen V. Straub, Andrea L. Meredith, M. Keith Wilkerson, Richard W. Aldrich, Mark T. Nelson

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (

Original language	English
Pages (from-to)	1397-1403
Number of pages	6
Journal	Nature Neuroscience
Volume	9
Issue number	11
DOIs	https://doi.org/10.1038/nn1779
Publication status	Published - Nov 2006

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title = "Local potassium signaling couples neuronal activity to vasodilation in the brain",

abstract = "The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (",

author = "Filosa, \{Jessica A.\} and Bonev, \{Adrian D.\} and Straub, \{Stephen V.\} and Meredith, \{Andrea L.\} and Wilkerson, \{M. Keith\} and Aldrich, \{Richard W.\} and Nelson, \{Mark T.\}",

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doi = "10.1038/nn1779",

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AU - Filosa, Jessica A.

AU - Bonev, Adrian D.

AU - Straub, Stephen V.

AU - Meredith, Andrea L.

AU - Wilkerson, M. Keith

AU - Aldrich, Richard W.

AU - Nelson, Mark T.

PY - 2006/11

Y1 - 2006/11

N2 - The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (

AB - The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (

U2 - 10.1038/nn1779

DO - 10.1038/nn1779

M3 - Article

SN - 1097-6256

VL - 9

SP - 1397

EP - 1403

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 11

ER -

Local potassium signaling couples neuronal activity to vasodilation in the brain

Abstract

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