Localised micro-mechanical stiffening in the ageing aorta

Helen K. Graham; Riaz Akhtar; Constantinos Kridiotis; Brian Derby; Tribikram Kundu; Andrew W. Trafford; Michael J. Sherratt

doi:10.1016/j.mad.2011.07.003

Localised micro-mechanical stiffening in the ageing aorta

Helen K. Graham, Riaz Akhtar, Constantinos Kridiotis, Brian Derby, Tribikram Kundu, Andrew W. Trafford, Michael J. Sherratt

Research output: Contribution to journal › Article › peer-review

Abstract

Age-related loss of tissue elasticity is a common cause of human morbidity and arteriosclerosis (vascular stiffening) is associated with the development of both fatal strokes and heart failure. However, in the absence of appropriate micro-mechanical testing methodologies, multiple structural remodelling events have been proposed as the cause of arteriosclerosis. Therefore, using a model of ageing in female sheep aorta (young: 8 years) we: (i) quantified age-related macro-mechanical stiffness, (ii) localised in situ micro-metre scale changes in acoustic wave speed (a measure of tissue stiffness) and (iii) characterised collagen and elastic fibre remodelling. With age, there was an increase in both macro-mechanical stiffness and mean microscopic wave speed (and hence stiffness; young wave speed: 1701±1ms -1, old wave speed: 1710±1ms -1, p

Original language	English
Pages (from-to)	459-467
Number of pages	8
Journal	Mechanisms of Ageing and Development
Volume	132
Issue number	10
DOIs	https://doi.org/10.1016/j.mad.2011.07.003
Publication status	Published - Oct 2011

Keywords

Arteriosclerosis
Collagen
Elastic fibers
Scanning acoustic microscopy
Tissue elasticity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mad.2011.07.003

Cite this

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title = "Localised micro-mechanical stiffening in the ageing aorta",

abstract = "Age-related loss of tissue elasticity is a common cause of human morbidity and arteriosclerosis (vascular stiffening) is associated with the development of both fatal strokes and heart failure. However, in the absence of appropriate micro-mechanical testing methodologies, multiple structural remodelling events have been proposed as the cause of arteriosclerosis. Therefore, using a model of ageing in female sheep aorta (young: 8 years) we: (i) quantified age-related macro-mechanical stiffness, (ii) localised in situ micro-metre scale changes in acoustic wave speed (a measure of tissue stiffness) and (iii) characterised collagen and elastic fibre remodelling. With age, there was an increase in both macro-mechanical stiffness and mean microscopic wave speed (and hence stiffness; young wave speed: 1701±1ms -1, old wave speed: 1710±1ms -1, p",

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AU - Graham, Helen K.

AU - Akhtar, Riaz

AU - Kridiotis, Constantinos

AU - Derby, Brian

AU - Kundu, Tribikram

AU - Trafford, Andrew W.

AU - Sherratt, Michael J.

PY - 2011/10

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AB - Age-related loss of tissue elasticity is a common cause of human morbidity and arteriosclerosis (vascular stiffening) is associated with the development of both fatal strokes and heart failure. However, in the absence of appropriate micro-mechanical testing methodologies, multiple structural remodelling events have been proposed as the cause of arteriosclerosis. Therefore, using a model of ageing in female sheep aorta (young: 8 years) we: (i) quantified age-related macro-mechanical stiffness, (ii) localised in situ micro-metre scale changes in acoustic wave speed (a measure of tissue stiffness) and (iii) characterised collagen and elastic fibre remodelling. With age, there was an increase in both macro-mechanical stiffness and mean microscopic wave speed (and hence stiffness; young wave speed: 1701±1ms -1, old wave speed: 1710±1ms -1, p

KW - Arteriosclerosis

KW - Collagen

KW - Elastic fibers

KW - Scanning acoustic microscopy

KW - Tissue elasticity

U2 - 10.1016/j.mad.2011.07.003

DO - 10.1016/j.mad.2011.07.003

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EP - 467

JO - Mechanisms of Ageing and Development

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ER -

Localised micro-mechanical stiffening in the ageing aorta

Abstract

Keywords

UN SDGs

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