Locus Coeruleus Noradrenergic Neurons and Astroglia in Health and Disease

Robert Zorec, Nina Vardjan, Alexei Verkhratsky

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The diffuse canvas of neuronal projections, arising from the brainstem locus coeruleus (LC) nucleus, is the primary sourc of noradrenaline (NA) in the central nervous system (CNS). During development the network of LC neurons develop in parallel with the neocortex, while projections of these neurons innervate virtually all areas in the CNS. The dense vascularization of the LC, and its proximity to the ventricles indicates high metabolic activity and vulnerability of these clls, which, in pathologic conditions can lead to the LC cll death, an early event in Parkinson's and Alzheimer's diseases. Reduced availability of NA affects astrocytes, the key homeostasis-providing clls in the CNS. Thus maintenanc in the LC nucleus and/or enhancment of mechanisms that mimic the action of NA, delays the onset of clinical signs in neurodegeneration, a new strategy to mitigate neurodegeneration.

Original languageEnglish
Title of host publicationNoradrenergic Signaling and Astroglia
EditorsNina Vardjan, Robert Zorec
PublisherElsevier BV
Number of pages25
ISBN (Electronic)9780128134269
ISBN (Print)9780128050880
Publication statusPublished - 21 Jul 2017


  • Aerobic glycolysis
  • Astrocytes
  • CAMP
  • Cytosolic Ca
  • Gliocrine system
  • Gliosignaling molecules
  • Glucose metabolism
  • Locus coeruleus
  • Neurodegeneration
  • Noradrenaline
  • Regulated exocytosis
  • Signaling
  • Vesicle dynamics


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