Long-term inhaled corticosteroids in preschool children at high risk for asthma

Theresa W. Guilbert; Wayne J. Morgan; Robert S. Zeiger; David T. Mauger; Susan J. Boehmer; Stanley J. Szefler; Leonard B. Bacharier; Robert F. Lemanske; Robert C. Strunk; David B. Allen; Gordon R. Bloomberg; Gregory Heldt; Marzena Krawiec; Gary Larsen; Andrew H. Liu; Vernon M. Chinchilli; Christine A. Sorkness; Lynn M. Taussig; Fernando D. Martinez

doi:10.1056/NEJMoa051378

Long-term inhaled corticosteroids in preschool children at high risk for asthma

Theresa W. Guilbert, Wayne J. Morgan, Robert S. Zeiger, David T. Mauger, Susan J. Boehmer, Stanley J. Szefler, Leonard B. Bacharier, Robert F. Lemanske, Robert C. Strunk, David B. Allen, Gordon R. Bloomberg, Gregory Heldt, Marzena Krawiec, Gary Larsen, Andrew H. Liu, Vernon M. Chinchilli, Christine A. Sorkness, Lynn M. Taussig, Fernando D. Martinez

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS: We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 ìg twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year. RESULTS: During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P

Original language	English
Pages (from-to)	1985-1997
Number of pages	12
Journal	New England Journal Of Medicine
Volume	354
Issue number	19
DOIs	https://doi.org/10.1056/NEJMoa051378
Publication status	Published - 11 May 2006

Keywords

Administration, Inhalation
Analysis of Variance
administration & dosage: Androstadienes
drug therapy: Asthma
administration & dosage: Bronchodilator Agents
Child, Preschool
Disease Progression
Disease-Free Survival
Female
drug effects: Growth
Humans
Male
Regression Analysis
drug effects: Respiratory Physiology
drug effects: Respiratory Sounds
Risk Factors
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1056/NEJMoa051378

http://content.nejm.org/cgi/reprint/354/19/1985.pdf

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Guilbert, T. W., Morgan, W. J., Zeiger, R. S., Mauger, D. T., Boehmer, S. J., Szefler, S. J., Bacharier, L. B., Lemanske, R. F., Strunk, R. C., Allen, D. B., Bloomberg, G. R., Heldt, G., Krawiec, M., Larsen, G., Liu, A. H., Chinchilli, V. M., Sorkness, C. A., Taussig, L. M., & Martinez, F. D. (2006). Long-term inhaled corticosteroids in preschool children at high risk for asthma. New England Journal Of Medicine, 354(19), 1985-1997. https://doi.org/10.1056/NEJMoa051378

@article{e22df80e90bb4bcd86882682fbdd0a85,

title = "Long-term inhaled corticosteroids in preschool children at high risk for asthma",

abstract = "BACKGROUND: It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS: We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 {\`i}g twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year. RESULTS: During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P",

keywords = "Administration, Inhalation, Analysis of Variance, administration & dosage: Androstadienes, drug therapy: Asthma, administration & dosage: Bronchodilator Agents, Child, Preschool, Disease Progression, Disease-Free Survival, Female, drug effects: Growth, Humans, Male, Regression Analysis, drug effects: Respiratory Physiology, drug effects: Respiratory Sounds, Risk Factors, Treatment Outcome",

author = "Guilbert, {Theresa W.} and Morgan, {Wayne J.} and Zeiger, {Robert S.} and Mauger, {David T.} and Boehmer, {Susan J.} and Szefler, {Stanley J.} and Bacharier, {Leonard B.} and Lemanske, {Robert F.} and Strunk, {Robert C.} and Allen, {David B.} and Bloomberg, {Gordon R.} and Gregory Heldt and Marzena Krawiec and Gary Larsen and Liu, {Andrew H.} and Chinchilli, {Vernon M.} and Sorkness, {Christine A.} and Taussig, {Lynn M.} and Martinez, {Fernando D.}",

year = "2006",

month = may,

day = "11",

doi = "10.1056/NEJMoa051378",

language = "English",

volume = "354",

pages = "1985--1997",

journal = "New England Journal Of Medicine",

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Guilbert, TW, Morgan, WJ, Zeiger, RS, Mauger, DT, Boehmer, SJ, Szefler, SJ, Bacharier, LB, Lemanske, RF, Strunk, RC, Allen, DB, Bloomberg, GR, Heldt, G, Krawiec, M, Larsen, G, Liu, AH, Chinchilli, VM, Sorkness, CA, Taussig, LM & Martinez, FD 2006, 'Long-term inhaled corticosteroids in preschool children at high risk for asthma', New England Journal Of Medicine, vol. 354, no. 19, pp. 1985-1997. https://doi.org/10.1056/NEJMoa051378

TY - JOUR

T1 - Long-term inhaled corticosteroids in preschool children at high risk for asthma

AU - Guilbert, Theresa W.

AU - Morgan, Wayne J.

AU - Zeiger, Robert S.

AU - Mauger, David T.

AU - Boehmer, Susan J.

AU - Szefler, Stanley J.

AU - Bacharier, Leonard B.

AU - Lemanske, Robert F.

AU - Strunk, Robert C.

AU - Allen, David B.

AU - Bloomberg, Gordon R.

AU - Heldt, Gregory

AU - Krawiec, Marzena

AU - Larsen, Gary

AU - Liu, Andrew H.

AU - Chinchilli, Vernon M.

AU - Sorkness, Christine A.

AU - Taussig, Lynn M.

AU - Martinez, Fernando D.

PY - 2006/5/11

Y1 - 2006/5/11

N2 - BACKGROUND: It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS: We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 ìg twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year. RESULTS: During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P

AB - BACKGROUND: It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS: We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 ìg twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year. RESULTS: During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P

KW - Administration, Inhalation

KW - Analysis of Variance

KW - administration & dosage: Androstadienes

KW - drug therapy: Asthma

KW - administration & dosage: Bronchodilator Agents

KW - Child, Preschool

KW - Disease Progression

KW - Disease-Free Survival

KW - Female

KW - drug effects: Growth

KW - Humans

KW - Male

KW - Regression Analysis

KW - drug effects: Respiratory Physiology

KW - drug effects: Respiratory Sounds

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1056/NEJMoa051378

DO - 10.1056/NEJMoa051378

M3 - Article

SN - 1533-4406

VL - 354

SP - 1985

EP - 1997

JO - New England Journal Of Medicine

JF - New England Journal Of Medicine

IS - 19

ER -

Long-term inhaled corticosteroids in preschool children at high risk for asthma

Abstract

Keywords

UN SDGs

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