TY - JOUR
T1 - Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: The U.K. TAVI (United Kingdom transcatheter aortic valve implantation) registry
AU - Moat, Neil E.
AU - Ludman, Peter
AU - De Belder, Mark A.
AU - Bridgewater, Ben
AU - Cunningham, Andrew D.
AU - Young, Christopher P.
AU - Thomas, Martyn
AU - Kovac, Jan
AU - Spyt, Tom
AU - MacCarthy, Philip A.
AU - Wendler, Olaf
AU - Hildick-Smith, David
AU - Davies, Simon W.
AU - Trivedi, Uday
AU - Blackman, Daniel J.
AU - Levy, Richard D.
AU - Brecker, Stephen J D
AU - Baumbach, Andreas
AU - Daniel, Tim
AU - Gray, Huon
AU - Mullen, Michael J.
PY - 2011/11/8
Y1 - 2011/11/8
N2 - Objectives: The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. Background: Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients. Methods: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010. Results: Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction
AB - Objectives: The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. Background: Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients. Methods: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010. Results: Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction
KW - aortic stenosis
KW - registry
KW - transcatheter aortic valve implantation
U2 - 10.1016/j.jacc.2011.08.050
DO - 10.1016/j.jacc.2011.08.050
M3 - Article
C2 - 22019110
SN - 0735-1097
VL - 58
SP - 2130
EP - 2138
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 20
ER -
