Abstract
Purpose To evaluate long-term radiation toxicity and biochemical control of two moderately hypofractionated radiotherapy regimens for prostate cancer. Material and methods Eligible men with localized prostate cancer received image-guided intensity modulated radiotherapy (IG-IMRT) to a dose of 60 or 66 Gy in 3 Gy fractions in a phase II trial. Endpoints included late gastrointestinal (GI) and genitourinary (GU) toxicity and biochemical failure (FFBF). Results Ninety-six men received 60 Gy and 27 received 66 Gy. Accrual to the 66 Gy cohort terminated early due to excessive Grade 3–4 late toxicity. Median follow-up was 128 months (60 Gy) and 108 months (66 Gy). In the 60 Gy cohort, cumulative late Grade ⩾2 GI and GU toxicity at 8 years was 4% and 12% respectively. In the 66 Gy cohort, late Grade ⩾2 GI and GU toxicity was 21% and 4% respectively at 8 years. The 5- and 8-year FFBF for 60 Gy was 81% and 66%, and for 66 Gy was 88% and 80%. Conclusions Moderate hypofractionation with IG-IMRT to 60 Gy was associated with favorable late toxicity although late urinary toxicity and biochemical failures were observed beyond 5 years. Dose escalation to 66 Gy was associated with significantly worse late toxicity.
Original language | English |
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Pages (from-to) | 93-98 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 122 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2017 |
Keywords
- Hypofractionation
- Late toxicity
- Outcomes
- Prostate cancer
- Radiotherapy
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre