Long-term outcomes of a phase II trial of moderate hypofractionated image-guided intensity modulated radiotherapy (IG-IMRT) for localized prostate cancer

Hester Lieng, Melania Pintilie, Andrew Bayley, Alejandro Berlin, Robert Bristow, Peter Chung, Mary Gospodarowicz, Roger Huang, Cynthia Ménard, Padraig Warde, Charles Catton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To evaluate long-term radiation toxicity and biochemical control of two moderately hypofractionated radiotherapy regimens for prostate cancer. Material and methods Eligible men with localized prostate cancer received image-guided intensity modulated radiotherapy (IG-IMRT) to a dose of 60 or 66 Gy in 3 Gy fractions in a phase II trial. Endpoints included late gastrointestinal (GI) and genitourinary (GU) toxicity and biochemical failure (FFBF). Results Ninety-six men received 60 Gy and 27 received 66 Gy. Accrual to the 66 Gy cohort terminated early due to excessive Grade 3–4 late toxicity. Median follow-up was 128 months (60 Gy) and 108 months (66 Gy). In the 60 Gy cohort, cumulative late Grade ⩾2 GI and GU toxicity at 8 years was 4% and 12% respectively. In the 66 Gy cohort, late Grade ⩾2 GI and GU toxicity was 21% and 4% respectively at 8 years. The 5- and 8-year FFBF for 60 Gy was 81% and 66%, and for 66 Gy was 88% and 80%. Conclusions Moderate hypofractionation with IG-IMRT to 60 Gy was associated with favorable late toxicity although late urinary toxicity and biochemical failures were observed beyond 5 years. Dose escalation to 66 Gy was associated with significantly worse late toxicity.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalRadiotherapy and Oncology
Volume122
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Hypofractionation
  • Late toxicity
  • Outcomes
  • Prostate cancer
  • Radiotherapy

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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