Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.

J T Moller; P Cluitmans; L S Rasmussen; P Houx; H Rasmussen; J Canet; P Rabbitt; J Jolles; K Larsen; C D Hanning; O Langeron; T Johnson; P M Lauven; P A Kristensen; A Biedler; H van Beem; O Fraidakis; J H Silverstein; J E Beneken; J S Gravenstein

Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.

J T Moller, P Cluitmans, L S Rasmussen, P Houx, H Rasmussen, J Canet, P Rabbitt, J Jolles, K Larsen, C D Hanning, O Langeron, T Johnson, P M Lauven, P A Kristensen, A Biedler, H van Beem, O Fraidakis, J H Silverstein, J E Beneken, J S Gravenstein

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Long-term postoperative cognitive dysfunction may occur in the elderly. Age may be a risk factor and hypoxaemia and arterial hypotension causative factors. We investigated these hypotheses in an international multicentre study. METHODS: 1218 patients aged at least 60 years completed neuropsychological tests before and 1 week and 3 months after major non-cardiac surgery. We measured oxygen saturation by continuous pulse oximetry before surgery and throughout the day of and the first 3 nights after surgery. We recorded blood pressure every 3 min by oscillometry during the operation and every 15-30 min for the rest of that day and night. We identified postoperative cognitive dysfunction with neuropsychological tests compared with controls recruited from the UK (n=176) and the same countries as study centres (n=145). FINDINGS: Postoperative cognitive dysfunction was present in 266 (25.8% [95% CI 23.1-28.5]) of patients 1 week after surgery and in 94 (9.9% [8.1-12.0]) 3 months after surgery, compared with 3.4% and 2.8%, respectively, of UK controls (p

Original language	English
Journal	Lancet
Volume	351
Issue number	9106
Publication status	Published - 21 Mar 1998

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Moller, J. T., Cluitmans, P., Rasmussen, L. S., Houx, P., Rasmussen, H., Canet, J., Rabbitt, P., Jolles, J., Larsen, K., Hanning, C. D., Langeron, O., Johnson, T., Lauven, P. M., Kristensen, P. A., Biedler, A., van Beem, H., Fraidakis, O., Silverstein, J. H., Beneken, J. E., & Gravenstein, J. S. (1998). Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet, 351(9106).

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title = "Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.",

abstract = "BACKGROUND: Long-term postoperative cognitive dysfunction may occur in the elderly. Age may be a risk factor and hypoxaemia and arterial hypotension causative factors. We investigated these hypotheses in an international multicentre study. METHODS: 1218 patients aged at least 60 years completed neuropsychological tests before and 1 week and 3 months after major non-cardiac surgery. We measured oxygen saturation by continuous pulse oximetry before surgery and throughout the day of and the first 3 nights after surgery. We recorded blood pressure every 3 min by oscillometry during the operation and every 15-30 min for the rest of that day and night. We identified postoperative cognitive dysfunction with neuropsychological tests compared with controls recruited from the UK (n=176) and the same countries as study centres (n=145). FINDINGS: Postoperative cognitive dysfunction was present in 266 (25.8% [95% CI 23.1-28.5]) of patients 1 week after surgery and in 94 (9.9% [8.1-12.0]) 3 months after surgery, compared with 3.4% and 2.8%, respectively, of UK controls (p",

author = "Moller, {J T} and P Cluitmans and Rasmussen, {L S} and P Houx and H Rasmussen and J Canet and P Rabbitt and J Jolles and K Larsen and Hanning, {C D} and O Langeron and T Johnson and Lauven, {P M} and Kristensen, {P A} and A Biedler and {van Beem}, H and O Fraidakis and Silverstein, {J H} and Beneken, {J E} and Gravenstein, {J S}",

year = "1998",

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journal = "Lancet",

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Moller, JT, Cluitmans, P, Rasmussen, LS, Houx, P, Rasmussen, H, Canet, J, Rabbitt, P, Jolles, J, Larsen, K, Hanning, CD, Langeron, O, Johnson, T, Lauven, PM, Kristensen, PA, Biedler, A, van Beem, H, Fraidakis, O, Silverstein, JH, Beneken, JE & Gravenstein, JS 1998, 'Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.', Lancet, vol. 351, no. 9106.

TY - JOUR

T1 - Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.

AU - Moller, J T

AU - Cluitmans, P

AU - Rasmussen, L S

AU - Houx, P

AU - Rasmussen, H

AU - Canet, J

AU - Rabbitt, P

AU - Jolles, J

AU - Larsen, K

AU - Hanning, C D

AU - Langeron, O

AU - Johnson, T

AU - Lauven, P M

AU - Kristensen, P A

AU - Biedler, A

AU - van Beem, H

AU - Fraidakis, O

AU - Silverstein, J H

AU - Beneken, J E

AU - Gravenstein, J S

PY - 1998/3/21

Y1 - 1998/3/21

N2 - BACKGROUND: Long-term postoperative cognitive dysfunction may occur in the elderly. Age may be a risk factor and hypoxaemia and arterial hypotension causative factors. We investigated these hypotheses in an international multicentre study. METHODS: 1218 patients aged at least 60 years completed neuropsychological tests before and 1 week and 3 months after major non-cardiac surgery. We measured oxygen saturation by continuous pulse oximetry before surgery and throughout the day of and the first 3 nights after surgery. We recorded blood pressure every 3 min by oscillometry during the operation and every 15-30 min for the rest of that day and night. We identified postoperative cognitive dysfunction with neuropsychological tests compared with controls recruited from the UK (n=176) and the same countries as study centres (n=145). FINDINGS: Postoperative cognitive dysfunction was present in 266 (25.8% [95% CI 23.1-28.5]) of patients 1 week after surgery and in 94 (9.9% [8.1-12.0]) 3 months after surgery, compared with 3.4% and 2.8%, respectively, of UK controls (p

AB - BACKGROUND: Long-term postoperative cognitive dysfunction may occur in the elderly. Age may be a risk factor and hypoxaemia and arterial hypotension causative factors. We investigated these hypotheses in an international multicentre study. METHODS: 1218 patients aged at least 60 years completed neuropsychological tests before and 1 week and 3 months after major non-cardiac surgery. We measured oxygen saturation by continuous pulse oximetry before surgery and throughout the day of and the first 3 nights after surgery. We recorded blood pressure every 3 min by oscillometry during the operation and every 15-30 min for the rest of that day and night. We identified postoperative cognitive dysfunction with neuropsychological tests compared with controls recruited from the UK (n=176) and the same countries as study centres (n=145). FINDINGS: Postoperative cognitive dysfunction was present in 266 (25.8% [95% CI 23.1-28.5]) of patients 1 week after surgery and in 94 (9.9% [8.1-12.0]) 3 months after surgery, compared with 3.4% and 2.8%, respectively, of UK controls (p

M3 - Article

C2 - 9525362

SN - 1474-547X

VL - 351

JO - Lancet

JF - Lancet

IS - 9106

ER -

Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.

Abstract

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